| 3. Journée | 28.02.2022 | Deportes Iquique | - | Deportes Temuco | 1:0 | ||||
| 4. Journée | 09.03.2022 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 5. Journée | 16.03.2022 | Deportes Iquique | - | CD Magallanes | 1:1 |  |
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| 6. Journée | 22.03.2022 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 7. Journée | 03.04.2022 | Deportes Iquique | - | Santa Cruz | 2:2 | ||||
| 8. Journée | 09.04.2022 | Fernández Vial | - | Deportes Iquique | 0:0 | ||||
| 9. Journée | 17.04.2022 | Deportes Iquique | - | Cobreloa | 2:0 | ||||
| 10. Journée | 20.04.2022 | Deportes Copiapó | - | Deportes Iquique | 1:0 | |
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| 11. Journée | 24.04.2022 | Deportes Iquique | - | Rangers | 0:2 | ||||
| 12. Journée | 30.04.2022 | Universidad de Concepción | - | Deportes Iquique | 2:2 | |
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| 13. Journée | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 14. Journée | 11.05.2022 | Barnechea | - | Deportes Iquique | 6:2 |
Argentine