| 1. Journée | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 5. Journée | 05.02.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 7. Journée | 19.02.2022 | Club Tijuana [] | - | CF Monterrey [] | 1:1 |  |
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| 12. Journée | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 14. Journée | 05.04.2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 | ||||
| 15. Journée | 20.04.2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | ||||
| 16. Journée | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 |
Mexique