| 1. Journée | 30.07.2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Journée | 07.08.2022 | Cerrito | - | Boston River | 0:3 |  |
|||
| 3. Journée | 12.08.2022 | Boston River | - | River Plate | 1:2 | |
|||
| 6. Journée | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | |
|||
| 5. Journée | 27.08.2022 | Boston River | - | Fénix | 1:1 | |
|||
| 4. Journée | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 7. Journée | 10.09.2022 | Boston River | - | Albion | 1:0 | |
|||
| 8. Journée | 15.09.2022 | Nacional | - | Boston River | 1:0 | ||||
| 9. Journée | 19.09.2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Journée | 24.09.2022 | Deportivo Maldonado | - | Boston River | 2:1 | ||||
| 11. Journée | 02.10.2022 | Boston River | - | Rentistas | 3:0 | |
|||
| 12. Journée | 09.10.2022 | Liverpool | - | Boston River | 3:2 | ||||
| 13. Journée | 13.10.2022 | Boston River | - | Peñarol | 2:1 | |
 |
||
| 14. Journée | 17.10.2022 | Montevideo City Torque | - | Boston River | 0:2 | ||||
| 15. Journée | 24.10.2022 | Boston River | - | Montevideo Wanderers | 2:2 |
Uruguay