| 1. Journée | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 2. Journée | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 |  |
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| 3. Journée | 19.02.2022 | River Plate | - | Boston River | 1:2 | ||||
| 5. Journée | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Journée | 20.03.2022 | River Plate | - | Fénix | 3:1 | ||||
| 7. Journée | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Journée | 10.04.2022 | River Plate | - | Albion | 4:1 |  |
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| 13. Journée | 22.05.2022 | Liverpool | - | River Plate | 2:1 |
Uruguay