| 1. Journée | 03.02.2018 | River Plate | - | Boston River | 2:2 |  |
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| 2. Journée | 11.02.2018 | Peñarol | - | River Plate | 4:1 | ||||
| 3. Journée | 18.02.2018 | River Plate | - | Atenas | 3:1 | ||||
| 4. Journée | 25.02.2018 | Danubio | - | River Plate | 1:0 | ||||
| 5. Journée | 04.03.2018 | River Plate | - | Torque | 2:2 | |
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| 6. Journée | 11.03.2018 | Rampla Juniors | - | River Plate | 1:2 | |
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| 7. Journée | 17.03.2018 | River Plate | - | Fénix | 2:1 | ||||
| 8. Journée | 25.03.2018 | Nacional | - | River Plate | 1:0 | ||||
| 9. Journée | 28.03.2018 | River Plate | - | Progreso | 4:2 | ||||
| 10. Journée | 01.04.2018 | Defensor Sporting | - | River Plate | 5:2 | |
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| 11. Journée | 08.04.2018 | River Plate | - | Racing | 1:1 | ||||
| 12. Journée | 14.04.2018 | River Plate | - | CA Cerro | 1:1 | ||||
| 13. Journée | 21.04.2018 | Montevideo Wanderers | - | River Plate | 0:3 | ||||
| 14. Journée | 29.04.2018 | River Plate | - | Liverpool | 5:0 |  |
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Uruguay