| 1. Journée | 01.09.2016 | Montevideo Wanderers | - | River Plate | 1:1 | ||||
| 2. Journée | 04.09.2016 | River Plate | - | Boston River | 1:5 |  |
|||
| 4. Journée | 18.09.2016 | River Plate | - | Defensor Sporting | 0:5 | ||||
| 5. Journée | 25.09.2016 | River Plate | - | Sud América | 0:3 | ||||
| 6. Journée | 01.10.2016 | River Plate | - | Fénix | 1:2 | ||||
| 7. Journée | 08.10.2016 | Liverpool | - | River Plate | 2:2 |  |
|||
| 8. Journée | 16.10.2016 | River Plate | - | Plaza Colonia | 2:1 |  |
|||
| 9. Journée | 23.10.2016 | Danubio | - | River Plate | 2:1 | |
|||
| 10. Journée | 30.10.2016 | Nacional | - | River Plate | 3:1 | |
|||
| 11. Journée | 13.11.2016 | Rampla Juniors | - | River Plate | 0:2 | ||||
| 12. Journée | 19.11.2016 | Racing | - | River Plate | 2:1 | |
|||
| 13. Journée | 26.11.2016 | River Plate | - | Villa Española | 2:1 | ||||
| 15. Journée | 10.12.2016 | CA Cerro | - | River Plate | 0:1 |
Uruguay