| 2. Journée | 27.02.2021 | Deportivo Cuenca | - | Guayaquil City | 3:0 | ||||
| 4. Journée | 13.03.2021 | Delfín SC | - | Guayaquil City | 1:1 |  |
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| 5. Journée | 21.03.2021 | Guayaquil City | - | Universidad Catolica | 1:2 | ||||
| 7. Journée | 01.04.2021 | Guayaquil City | - | Orense SC | 4:1 | ||||
| 6. Journée | 05.04.2021 | Técnico Universitario | - | Guayaquil City | 3:0 | ||||
| 10. Journée | 04.05.2021 | Olmedo | - | Guayaquil City | 0:0 | ||||
| 11. Journée | 11.05.2021 | Guayaquil City | - | Manta | 0:3 | ||||
| 12. Journée | 16.05.2021 | Emelec | - | Guayaquil City | 1:0 | |
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| 13. Journée | 22.05.2021 | Independiente del Valle | - | Guayaquil City | 3:0 | ||||
| 14. Journée | 29.05.2021 | Guayaquil City | - | Mushuc Runa | 0:0 |
Uruguay