| 5. Journée | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Journée | 22.03.2022 | Cerro Largo | - | Cerrito | 1:0 |  |
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| 7. Journée | 03.04.2022 | Fénix | - | Cerro Largo | 2:0 | |
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| 8. Journée | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | ||||
| 9. Journée | 16.04.2022 | Albion | - | Cerro Largo | 2:1 | |
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| 10. Journée | 23.04.2022 | Cerro Largo | - | Nacional | 0:2 | ||||
| 12. Journée | 15.05.2022 | Cerro Largo | - | Deportivo Maldonado | 1:0 | ||||
| 13. Journée | 21.05.2022 | Rentistas | - | Cerro Largo | 2:0 | ||||
| 14. Journée | 28.05.2022 | Cerro Largo | - | Liverpool | 1:2 | |
Uruguay