| 1. Journée | 01.09.1900 | Preston North End | - | Everton FC | 1:2 |  |
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| 25. Journée | 03.09.1900 | Aston Villa | - | Preston North End | 4:0 | ||||
| 2. Journée | 08.09.1900 | Sunderland AFC | - | Preston North End | 3:1 | ||||
| 3. Journée | 15.09.1900 | Preston North End | - | Derby County | 3:2 | ||||
| 4. Journée | 22.09.1900 | Bolton Wanderers | - | Preston North End | 1:1 | ||||
| 5. Journée | 29.09.1900 | Preston North End | - | Notts County | 0:1 | ||||
| 31. Journée | 04.10.1900 | Nottingham Forest | - | Preston North End | 4:1 | ||||
| 6. Journée | 06.10.1900 | The Wednesday FC | - | Preston North End | 0:1 | ||||
| 7. Journée | 13.10.1900 | Wolverhampton Wanderers | - | Preston North End | 2:2 | ||||
| 8. Journée | 20.10.1900 | Preston North End | - | Aston Villa | 0:2 | ||||
| 10. Journée | 03.11.1900 | Preston North End | - | Newcastle United | 0:1 | ||||
| 11. Journée | 10.11.1900 | Sheffield United | - | Preston North End | 2:1 | ||||
| 16. Journée | 26.12.1900 | Stoke City | - | Preston North End | 5:0 | ||||
| 19. Journée | 29.12.1900 | Everton FC | - | Preston North End | 4:1 |
Angleterre