| 1. Journée | 23.07.2021 | AS Trenčín | - | Zlaté Moravce | 4:0 | ||||
| 2. Journée | 31.07.2021 | Slovan Bratislava | - | AS Trenčín | 2:0 | ||||
| 3. Journée | 07.08.2021 | MFK Zemplín Michalovce | - | AS Trenčín | 1:2 | ||||
| 4. Journée | 13.08.2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Journée | 22.08.2021 | FC DAC 1904 | - | AS Trenčín | 1:1 | ||||
| 6. Journée | 28.08.2021 | AS Trenčín | - | ŠKF Sereď | 0:0 | ||||
| 7. Journée | 11.09.2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 8. Journée | 18.09.2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
| 11. Journée | 15.10.2021 | Tatran Liptovský Mikuláš | - | AS Trenčín | 2:1 |  |
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| 12. Journée | 23.10.2021 | Zlaté Moravce | - | AS Trenčín | 0:1 |  |
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| 13. Journée | 31.10.2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 15. Journée | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Journée | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 17. Journée | 04.12.2021 | ŠKF Sereď | - | AS Trenčín | 4:2 | ||||
| 18. Journée | 11.12.2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 19. Journée | 18.12.2021 | FK Senica | - | AS Trenčín | 1:0 | ||||
| 20. Journée | 12.02.2022 | AS Trenčín | - | FK Pohronie | 3:0 |
Slovaquie