| 1. Journée | 21.08.2021 | Cape Town City FC | - | SuperSport United | 0:0 | ||||
| 2. Journée | 25.08.2021 | Royal AM | - | Cape Town City FC | 1:2 | ||||
| 4. Journée | 18.09.2021 | Cape Town City FC | - | Stellenbosch FC | 0:3 | ||||
| 5. Journée | 24.09.2021 | Moroka Swallows | - | Cape Town City FC | 0:0 | ||||
| 6. Journée | 02.10.2021 | Cape Town City FC | - | Orlando Pirates | 1:1 | ||||
| 7. Journée | 16.10.2021 | Sekhukhune United | - | Cape Town City FC | 1:0 | ||||
| 11. Journée | 20.11.2021 | Cape Town City FC | - | Mamelodi Sundowns | 0:0 | ||||
| 12. Journée | 27.11.2021 | TS Galaxy | - | Cape Town City FC | 2:2 | ||||
| 15. Journée | 11.12.2021 | Baroka FC | - | Cape Town City FC | 0:0 | ||||
| 22. Journée | 14.12.2021 | Marumo Gallants | - | Cape Town City FC | 0:0 | ||||
| 16. Journée | 18.12.2021 | Cape Town City FC | - | Moroka Swallows | 2:1 |  |
Afrique du Sud