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| 01.10.2021 | 13:00 | FK Qo’qon 1912 | - | Pakhtakor Tashkent | 4:2 (2:0) | |
| 15:15 | Metallurg Bekobod | - | Lokomotiv Tashkent | 1:2 (1:0) | ||
| 02.10.2021 | 12:30 | FK Mash'al Muborak | - | FC Nasaf | 0:1 (0:1) | |
| 12:45 | Andijon PFK | - | So’g’diyona PFK | 0:0 (0:0) | ||
| 15:00 | Bunyodkor PFK | - | FC AGMK | 1:1 (0:0) | ||
| 03.10.2021 | 13:00 | Surkhon Termez FK | - | Navbahor Namangan | 1:0 (0:0) | |
| 15:15 | Qizilqum Zarafshon | - | FK Turon | 2:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pakhtakor Tashkent | 21 | 16 | 3 | 2 | 37:12 | 25 | 51 |
| 2 |
|
So’g’diyona PFK | 21 | 10 | 9 | 2 | 24:12 | 12 | 39 |
| 3 |
|
FC Nasaf | 21 | 11 | 4 | 6 | 35:18 | 17 | 37 |
| 4 |
|
FC AGMK | 21 | 10 | 7 | 4 | 25:18 | 7 | 37 |
| 5 |
|
Bunyodkor PFK | 21 | 9 | 6 | 6 | 32:24 | 8 | 33 |
| 6 |
|
Lokomotiv Tashkent | 21 | 9 | 5 | 7 | 30:24 | 6 | 32 |
| 7 |
|
Qizilqum Zarafshon | 21 | 7 | 10 | 4 | 22:18 | 4 | 31 |
| 8 |
|
Navbahor Namangan | 21 | 7 | 8 | 6 | 16:14 | 2 | 29 |
| 9 |
|
FK Qo’qon 1912 | 21 | 7 | 7 | 7 | 28:27 | 1 | 28 |
| 10 |
|
Metallurg Bekobod | 21 | 6 | 1 | 14 | 18:31 | -13 | 19 |
| 11 |
|
FK Mash'al Muborak | 21 | 4 | 6 | 11 | 17:30 | -13 | 18 |
| 12 |
|
Surkhon Termez FK | 21 | 5 | 3 | 13 | 13:34 | -21 | 18 |
| 13 |
|
Andijon PFK | 21 | 4 | 5 | 12 | 16:32 | -16 | 17 |
| 14 |
|
FK Turon | 21 | 2 | 6 | 13 | 13:32 | -19 | 12 |
| Champions League | |
| Champions League Quali. | |
| Relégation | |
| Relégation |
