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| 25.09.2021 | 13:00 | FK Qo’qon 1912 | - | Andijon PFK | 1:1 (0:0) | |
| 15:30 | Pakhtakor Tashkent | - | FK Turon | 3:1 (1:0) | ||
| 26.09.2021 | 13:15 | So’g’diyona PFK | - | Metallurg Bekobod | 2:0 (1:0) | |
| 15:30 | FC AGMK | - | Surkhon Termez FK | 1:0 (0:0) | ||
| 15:30 | Navbahor Namangan | - | Qizilqum Zarafshon | 0:0 (0:0) | ||
| 27.09.2021 | 16:00 | Lokomotiv Tashkent | - | FK Mash'al Muborak | 2:1 (0:1) | |
| 16:00 | FC Nasaf | - | Bunyodkor PFK | 5:0 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pakhtakor Tashkent | 20 | 16 | 3 | 1 | 35:8 | 27 | 51 |
| 2 |
|
So’g’diyona PFK | 20 | 10 | 8 | 2 | 24:12 | 12 | 38 |
| 3 |
|
FC AGMK | 20 | 10 | 6 | 4 | 24:17 | 7 | 36 |
| 4 |
|
FC Nasaf | 20 | 10 | 4 | 6 | 34:18 | 16 | 34 |
| 5 |
|
Bunyodkor PFK | 20 | 9 | 5 | 6 | 31:23 | 8 | 32 |
| 6 |
|
Lokomotiv Tashkent | 20 | 8 | 5 | 7 | 28:23 | 5 | 29 |
| 7 |
|
Navbahor Namangan | 20 | 7 | 8 | 5 | 16:13 | 3 | 29 |
| 8 |
|
Qizilqum Zarafshon | 20 | 6 | 10 | 4 | 20:17 | 3 | 28 |
| 9 |
|
FK Qo’qon 1912 | 20 | 6 | 7 | 7 | 24:25 | -1 | 25 |
| 10 |
|
Metallurg Bekobod | 20 | 6 | 1 | 13 | 17:29 | -12 | 19 |
| 11 |
|
FK Mash'al Muborak | 20 | 4 | 6 | 10 | 17:29 | -12 | 18 |
| 12 |
|
Andijon PFK | 20 | 4 | 4 | 12 | 16:32 | -16 | 16 |
| 13 |
|
Surkhon Termez FK | 20 | 4 | 3 | 13 | 12:34 | -22 | 15 |
| 14 |
|
FK Turon | 20 | 2 | 6 | 12 | 12:30 | -18 | 12 |
| Champions League | |
| Champions League Quali. | |
| Relégation | |
| Relégation |
