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| 25.08.2021 | 14:00 | FK Qo’qon 1912 | - | Surkhon Termez FK | 2:0 (2:0) | |
| 16:00 | Metallurg Bekobod | - | FK Mash'al Muborak | 1:2 (0:1) | ||
| 16:00 | So’g’diyona PFK | - | Qizilqum Zarafshon | 2:1 (1:0) | ||
| 26.08.2021 | 14:00 | Andijon PFK | - | Bunyodkor PFK | 1:4 (1:1) | |
| 16:00 | Pakhtakor Tashkent | - | FC AGMK | 1:0 (1:0) | ||
| 27.08.2021 | 16:00 | Lokomotiv Tashkent | - | FK Turon | 3:1 (1:1) | |
| 29.08.2021 | 16:00 | FC Nasaf | - | Navbahor Namangan | 0:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pakhtakor Tashkent | 16 | 14 | 2 | 0 | 29:6 | 23 | 44 |
| 2 |
|
So’g’diyona PFK | 16 | 8 | 6 | 2 | 21:12 | 9 | 30 |
| 3 |
|
FC AGMK | 16 | 8 | 4 | 4 | 21:17 | 4 | 28 |
| 4 |
|
Bunyodkor PFK | 16 | 7 | 4 | 5 | 26:15 | 11 | 25 |
| 5 |
|
Qizilqum Zarafshon | 16 | 6 | 7 | 3 | 19:15 | 4 | 25 |
| 6 |
|
FC Nasaf | 16 | 7 | 3 | 6 | 23:15 | 8 | 24 |
| 7 |
|
Navbahor Namangan | 16 | 6 | 5 | 5 | 15:13 | 2 | 23 |
| 8 |
|
Lokomotiv Tashkent | 16 | 6 | 4 | 6 | 22:19 | 3 | 22 |
| 9 |
|
FK Qo’qon 1912 | 16 | 5 | 5 | 6 | 19:20 | -1 | 20 |
| 10 |
|
FK Mash'al Muborak | 16 | 4 | 4 | 8 | 14:24 | -10 | 16 |
| 11 |
|
Metallurg Bekobod | 16 | 5 | 1 | 10 | 15:22 | -7 | 16 |
| 12 |
|
Surkhon Termez FK | 16 | 4 | 2 | 10 | 10:28 | -18 | 14 |
| 13 |
|
FK Turon | 16 | 2 | 6 | 8 | 11:22 | -11 | 12 |
| 14 |
|
Andijon PFK | 16 | 2 | 3 | 11 | 12:29 | -17 | 9 |
| Champions League | |
| Champions League Quali. | |
| Relégation | |
| Relégation |
