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| 21.07.2021 | 23:00 | CA Cerro | - | Uruguay Montevideo | 0:1 (0:1) | |
| 22.07.2021 | 01:30 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 (1:0) | |
| 19:15 | Atenas | - | Racing | 0:0 (0:0) | ||
| 21:45 | Danubio | - | Albion | 0:2 (0:1) | ||
| 23.07.2021 | 00:15 | Rocha | - | Rampla Juniors | 2:0 (1:0) | |
| 24.07.2021 | 17:45 | Central Español | - | Villa Teresa | 2:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing | 8 | 5 | 3 | 0 | 13:6 | 7 | 18 |
| 2 |
|
Juventud de Las Piedras | 8 | 5 | 0 | 3 | 13:8 | 5 | 15 |
| 3 |
|
Albion | 8 | 4 | 2 | 2 | 12:9 | 3 | 14 |
| 4 |
|
Danubio | 8 | 4 | 2 | 2 | 6:5 | 1 | 14 |
| 5 |
|
Rocha | 8 | 3 | 2 | 3 | 13:12 | 1 | 11 |
| 6 |
|
Defensor Sporting | 8 | 3 | 2 | 3 | 12:11 | 1 | 11 |
| 7 |
|
Atenas | 8 | 2 | 4 | 2 | 8:5 | 3 | 10 |
| 8 |
|
Uruguay Montevideo | 8 | 3 | 1 | 4 | 9:9 | 0 | 10 |
| 9 |
|
Central Español | 8 | 3 | 1 | 4 | 9:15 | -6 | 10 |
| 10 |
|
CA Cerro | 8 | 1 | 4 | 3 | 7:10 | -3 | 7 |
| 11 |
|
Rampla Juniors | 8 | 1 | 3 | 4 | 4:10 | -6 | 6 |
| 12 |
|
Villa Teresa | 8 | 1 | 2 | 5 | 8:14 | -6 | 5 |
| Promotion | |
| Play-off |
