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| 03.12.2021 | 16:00 | Shakhtar Donetsk | - | FK Lviv | 6:1 (1:1) | |
| 04.12.2021 | 13:00 | NK Veres | - | Dinamo Kiev | 0:3 (0:1) | |
| 16:00 | Rukh Lviv | - | Vorskla Poltava | 0:0 (0:0) | ||
| 18:30 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 (0:1) | ||
| 05.12.2021 | 13:00 | Zorya Lugansk | - | Inhulets Petrove | 1:0 (0:0) | |
| 16:00 | FK Oleksandriya | - | FC Mynai | 3:0 (2:0) | ||
| 18:30 | Desna Chernigov | - | FK Mariupol | 3:3 (0:1) | ||
| 06.12.2021 | 18:30 | SK Dnipro-1 | - | Chernomorets Odessa | 3:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Shakhtar Donetsk | 17 | 14 | 2 | 1 | 47:9 | 38 | 44 |
| 2 |
|
Dinamo Kiev | 17 | 14 | 2 | 1 | 46:8 | 38 | 44 |
| 3 |
|
SK Dnipro-1 | 17 | 12 | 1 | 4 | 32:17 | 15 | 37 |
| 4 |
|
Zorya Lugansk | 17 | 11 | 2 | 4 | 36:18 | 18 | 35 |
| 5 |
|
Vorskla Poltava | 17 | 9 | 5 | 3 | 29:17 | 12 | 32 |
| 6 |
|
FK Oleksandriya | 17 | 7 | 5 | 5 | 18:14 | 4 | 26 |
| 7 |
|
Desna Chernigov | 17 | 7 | 4 | 6 | 21:25 | -4 | 25 |
| 8 |
|
NK Veres | 17 | 6 | 4 | 7 | 14:19 | -5 | 22 |
| 9 |
|
Kolos Kovalivka | 17 | 6 | 3 | 8 | 12:22 | -10 | 21 |
| 10 |
|
Metalist 1925 Kharkiv | 17 | 6 | 1 | 10 | 16:27 | -11 | 19 |
| 11 |
|
Rukh Lviv | 16 | 4 | 5 | 7 | 15:20 | -5 | 17 |
| 12 |
|
FK Lviv | 17 | 4 | 4 | 9 | 13:29 | -16 | 16 |
| 13 |
|
Chernomorets Odessa | 17 | 2 | 5 | 10 | 18:39 | -21 | 11 |
| 14 |
|
Inhulets Petrove | 16 | 2 | 4 | 10 | 11:27 | -16 | 10 |
| 15 |
|
FC Mynai | 17 | 1 | 7 | 9 | 11:28 | -17 | 10 |
| 16 |
|
FK Mariupol | 17 | 2 | 2 | 13 | 21:41 | -20 | 8 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
