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| 26.11.2021 | 18:30 | FK Mariupol | - | FK Lviv | 0:1 (0:0) | |
| 27.11.2021 | 13:00 | FC Mynai | - | Dinamo Kiev | 0:2 (0:1) | |
| 16:00 | Chernomorets Odessa | - | Desna Chernigov | 0:1 (0:1) | ||
| 18:30 | SK Dnipro-1 | - | Vorskla Poltava | 5:1 (1:0) | ||
| 28.11.2021 | 13:00 | Inhulets Petrove | - | Shakhtar Donetsk | 0:1 (0:1) | |
| 16:00 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 (1:0) | ||
| 18:30 | Kolos Kovalivka | - | NK Veres | 1:0 (0:0) | ||
| 29.11.2021 | 18:30 | FK Oleksandriya | - | Zorya Lugansk | 0:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 16 | 13 | 2 | 1 | 43:8 | 35 | 41 |
| 2 |
|
Shakhtar Donetsk | 16 | 13 | 2 | 1 | 41:8 | 33 | 41 |
| 3 |
|
SK Dnipro-1 | 16 | 11 | 1 | 4 | 29:16 | 13 | 34 |
| 4 |
|
Zorya Lugansk | 16 | 10 | 2 | 4 | 35:18 | 17 | 32 |
| 5 |
|
Vorskla Poltava | 16 | 9 | 4 | 3 | 29:17 | 12 | 31 |
| 6 |
|
Desna Chernigov | 16 | 7 | 3 | 6 | 18:22 | -4 | 24 |
| 7 |
|
FK Oleksandriya | 16 | 6 | 5 | 5 | 15:14 | 1 | 23 |
| 8 |
|
NK Veres | 16 | 6 | 4 | 6 | 14:16 | -2 | 22 |
| 9 |
|
Metalist 1925 Kharkiv | 16 | 6 | 1 | 9 | 16:26 | -10 | 19 |
| 10 |
|
Kolos Kovalivka | 16 | 5 | 3 | 8 | 11:22 | -11 | 18 |
| 11 |
|
Rukh Lviv | 15 | 4 | 4 | 7 | 15:20 | -5 | 16 |
| 12 |
|
FK Lviv | 16 | 4 | 4 | 8 | 12:23 | -11 | 16 |
| 13 |
|
Chernomorets Odessa | 16 | 2 | 5 | 9 | 17:36 | -19 | 11 |
| 14 |
|
FC Mynai | 16 | 1 | 7 | 8 | 11:25 | -14 | 10 |
| 15 |
|
Inhulets Petrove | 15 | 2 | 4 | 9 | 11:26 | -15 | 10 |
| 16 |
|
FK Mariupol | 16 | 2 | 1 | 13 | 18:38 | -20 | 7 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
