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| H (Match allé) | Sivas Belediyespor | - | Trabzonspor | 2:2 (1:1) | ||
| R (match retour) | Trabzonspor | - | Sivas Belediyespor | 5:0 (3:0) | ||
| H (Match allé): 04.12.2018 11:00 | R (match retour): 19.12.2018 18:30 | vainqueur: Trabzonspor | ||||
| H (Match allé) | Nazilli Belediyespor | - | Göztepe | 0:3 (0:1) | ||
| R (match retour) | Göztepe | - | Nazilli Belediyespor | 2:1 (1:1) | ||
| H (Match allé): 04.12.2018 12:45 | R (match retour): 18.12.2018 15:00 | vainqueur: Göztepe | ||||
| H (Match allé) | Gençlerbirliği | - | Hatayspor | 2:1 (0:0) | ||
| R (match retour) | Hatayspor | - | Gençlerbirliği | 2:0 (1:0) | ||
| H (Match allé): 04.12.2018 12:45 | R (match retour): 20.12.2018 11:00 | vainqueur: Hatayspor | ||||
| H (Match allé) | Antalyaspor | - | Darıca Gençlerbirliği | 2:2 (1:1) | ||
| R (match retour) | Darıca Gençlerbirliği | - | Antalyaspor | 0:1 (0:0) | ||
| H (Match allé): 04.12.2018 14:45 | R (match retour): 20.12.2018 11:45 | vainqueur: Antalyaspor | ||||
| H (Match allé) | Alanyaspor | - | Kahramanmaraşspor | 7:2 (1:1) | ||
| R (match retour) | Kahramanmaraşspor | - | Alanyaspor | 2:1 (0:0) | ||
| H (Match allé): 04.12.2018 16:30 | R (match retour): 19.12.2018 13:00 | vainqueur: Alanyaspor | ||||
| H (Match allé) | Çaykur Rizespor | - | Balıkesirspor | 0:2 (0:2) | ||
| R (match retour) | Balıkesirspor | - | Çaykur Rizespor | 1:1 (0:0) | ||
| H (Match allé): 04.12.2018 18:30 | R (match retour): 18.12.2018 13:00 | vainqueur: Balıkesirspor | ||||
| H (Match allé) | Keçiörengücü | - | Galatasaray | 1:2 (0:1) | ||
| R (match retour) | Galatasaray | - | Keçiörengücü | 1:1 (0:0) | ||
| H (Match allé): 05.12.2018 11:00 | R (match retour): 18.12.2018 18:30 | vainqueur: Galatasaray | ||||
| H (Match allé) | Ümraniyespor | - | 1461 Trabzon | 4:1 (1:0) | ||
| R (match retour) | 1461 Trabzon | - | Ümraniyespor | 3:1 (0:1) | ||
| H (Match allé): 05.12.2018 12:45 | R (match retour): 18.12.2018 11:00 | vainqueur: Ümraniyespor | ||||
| H (Match allé) | Boluspor | - | Van BBSK | 5:1 (0:0) | ||
| R (match retour) | Van BBSK | - | Boluspor | 2:2 (1:1) | ||
| H (Match allé): 05.12.2018 15:00 | R (match retour): 19.12.2018 11:00 | vainqueur: Boluspor | ||||
| H (Match allé) | Altay Izmir | - | Kayserispor | 1:2 (0:0) | ||
| R (match retour) | Kayserispor | - | Altay Izmir | 4:1 (2:0) | ||
| H (Match allé): 05.12.2018 16:30 | R (match retour): 19.12.2018 16:30 | vainqueur: Kayserispor | ||||
| H (Match allé) | Adana Demirspor | - | İstanbul Başakşehir | 1:1 (0:0) | ||
| R (match retour) | İstanbul Başakşehir | - | Adana Demirspor | 2:0 (2:0) | ||
| H (Match allé): 05.12.2018 18:30 | R (match retour): 18.12.2018 17:00 | vainqueur: İstanbul Başakşehir | ||||
| H (Match allé) | Bodrum Belediyesi | - | MKE Ankaragücü | 4:2 (0:0) | ||
| R (match retour) | MKE Ankaragücü | - | Bodrum Belediyesi | 3:2 (1:2) | ||
| H (Match allé): 06.12.2018 11:00 | R (match retour): 18.12.2018 11:45 | vainqueur: Bodrum Belediyesi | ||||
| H (Match allé) | Fatih Karagümrük | - | Akhisar Belediyespor | 1:4 (0:1) | ||
| R (match retour) | Akhisar Belediyespor | - | Fatih Karagümrük | 2:0 (0:0) | ||
| H (Match allé): 06.12.2018 13:00 | R (match retour): 20.12.2018 16:00 | vainqueur: Akhisar Belediyespor | ||||
| H (Match allé) | Menemen Belediyespor | - | Kasımpaşa SK | 1:2 (0:0) | ||
| R (match retour) | Kasımpaşa SK | - | Menemen Belediyespor | 4:1 (3:0) | ||
| H (Match allé): 06.12.2018 15:00 | R (match retour): 19.12.2018 15:00 | vainqueur: Kasımpaşa SK | ||||
| H (Match allé) | Yeni Malatyaspor | - | Etimesgut Belediyespor | 2:0 (0:0) | ||
| R (match retour) | Etimesgut Belediyespor | - | Yeni Malatyaspor | 0:2 (0:0) | ||
| H (Match allé): 06.12.2018 16:30 | R (match retour): 19.12.2018 11:45 | vainqueur: Yeni Malatyaspor | ||||
| H (Match allé) | Fenerbahçe | - | Giresunspor | 1:0 (0:0) | ||
| R (match retour) | Giresunspor | - | Fenerbahçe | 2:5 (1:1) | ||
| H (Match allé): 06.12.2018 18:30 | R (match retour): 20.12.2018 18:30 | vainqueur: Fenerbahçe | ||||
