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| 05.12.2021 | 11:00 | Bayburt İl Özel İdare | - | Adıyamanspor | 2:1 (1:1) | |
| 11:00 | Bodrum FK | - | Hekimoğlu Trabzon | 1:1 (0:0) | ||
| 11:00 | Çorum FK | - | Inegölspor | 0:1 (0:0) | ||
| 11:00 | Etimesgut Belediyespor | - | Somaspor | 2:2 (2:1) | ||
| 11:00 | Kahramanmaraşspor | - | Diyarbekirspor | 4:0 (1:0) | ||
| 11:00 | Sarıyer SK | - | Niğde Anadolu FK | 2:0 (0:0) | ||
| 11:00 | Serik Belediyespor | - | Ergene Velimeşe | 3:0 (2:0) | ||
| 11:00 | Sivas Belediyespor | - | Afjet Afyonspor | 3:4 (3:0) | ||
| 11:00 | Vanspor FK | - | Ankaraspor | 2:2 (1:1) | ||
| 06.12.2021 | 11:00 | Turgutluspor | - | Sakaryaspor | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 16 | 10 | 6 | 0 | 30:5 | 25 | 36 |
| 2 |
|
Hekimoğlu Trabzon | 16 | 9 | 7 | 0 | 29:10 | 19 | 34 |
| 3 |
|
Sivas Belediyespor | 16 | 9 | 3 | 4 | 32:13 | 19 | 30 |
| 4 |
|
Bayburt İl Özel İdare | 16 | 9 | 3 | 4 | 23:15 | 8 | 30 |
| 5 |
|
Afjet Afyonspor | 16 | 7 | 7 | 2 | 33:18 | 15 | 28 |
| 6 |
|
Çorum FK | 16 | 7 | 7 | 2 | 22:9 | 13 | 28 |
| 7 |
|
Bodrum FK | 16 | 8 | 3 | 5 | 26:13 | 13 | 27 |
| 8 |
|
Ankaraspor | 16 | 7 | 5 | 4 | 28:18 | 10 | 26 |
| 9 |
|
Somaspor | 16 | 7 | 5 | 4 | 26:21 | 5 | 26 |
| 10 |
|
Vanspor FK | 16 | 7 | 5 | 4 | 23:23 | 0 | 26 |
| 11 |
|
Inegölspor | 16 | 7 | 3 | 6 | 19:21 | -2 | 24 |
| 12 |
|
Serik Belediyespor | 16 | 7 | 2 | 7 | 22:23 | -1 | 23 |
| 13 |
|
Etimesgut Belediyespor | 16 | 5 | 5 | 6 | 18:23 | -5 | 20 |
| 14 |
|
Diyarbekirspor | 16 | 5 | 3 | 8 | 18:21 | -3 | 18 |
| 15 |
|
Turgutluspor | 16 | 4 | 6 | 6 | 19:27 | -8 | 18 |
| 16 |
|
Sarıyer SK | 16 | 4 | 3 | 9 | 16:24 | -8 | 15 |
| 17 |
|
Ergene Velimeşe | 16 | 3 | 2 | 11 | 13:34 | -21 | 11 |
| 18 |
|
Adıyamanspor | 16 | 3 | 1 | 12 | 19:32 | -13 | 10 |
| 19 |
|
Kahramanmaraşspor | 16 | 2 | 0 | 14 | 10:44 | -34 | 6 |
| 20 |
|
Niğde Anadolu FK | 16 | 1 | 2 | 13 | 10:42 | -32 | 5 |
| Promotion | |
| Play-off | |
| Relégation |
