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| 06.11.2021 | 10:00 | Adıyamanspor | - | Sakaryaspor | 0:3 (0:1) | |
| 11:00 | Afjet Afyonspor | - | Ergene Velimeşe | 2:0 (0:0) | ||
| 11:00 | Ankaraspor | - | Sivas Belediyespor | 0:2 (0:0) | ||
| 11:00 | Bodrum FK | - | Çorum FK | 1:2 (1:0) | ||
| 11:00 | Diyarbekirspor | - | Etimesgut Belediyespor | 2:1 (2:0) | ||
| 11:00 | Hekimoğlu Trabzon | - | Kahramanmaraşspor | 5:1 (4:0) | ||
| 11:00 | Inegölspor | - | Serik Belediyespor | 2:2 (1:0) | ||
| 11:00 | Niğde Anadolu FK | - | Turgutluspor | 1:1 (0:0) | ||
| 11:00 | Somaspor | - | Bayburt İl Özel İdare | 3:1 (0:0) | ||
| 11:00 | Vanspor FK | - | Sarıyer SK | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hekimoğlu Trabzon | 11 | 7 | 4 | 0 | 24:7 | 17 | 25 |
| 2 |
|
Sivas Belediyespor | 11 | 7 | 3 | 1 | 21:4 | 17 | 24 |
| 3 |
|
Çorum FK | 11 | 7 | 3 | 1 | 19:5 | 14 | 24 |
| 4 |
|
Sakaryaspor | 11 | 6 | 5 | 0 | 20:2 | 18 | 23 |
| 5 |
|
Vanspor FK | 11 | 7 | 2 | 2 | 18:14 | 4 | 23 |
| 6 |
|
Ankaraspor | 11 | 6 | 2 | 3 | 23:13 | 10 | 20 |
| 7 |
|
Bayburt İl Özel İdare | 11 | 6 | 2 | 3 | 17:11 | 6 | 20 |
| 8 |
|
Somaspor | 11 | 6 | 2 | 3 | 19:14 | 5 | 20 |
| 9 |
|
Bodrum FK | 11 | 6 | 1 | 4 | 19:9 | 10 | 19 |
| 10 |
|
Afjet Afyonspor | 11 | 4 | 6 | 1 | 18:13 | 5 | 18 |
| 11 |
|
Diyarbekirspor | 11 | 4 | 2 | 5 | 13:13 | 0 | 14 |
| 12 |
|
Etimesgut Belediyespor | 11 | 4 | 2 | 5 | 13:16 | -3 | 14 |
| 13 |
|
Serik Belediyespor | 11 | 4 | 1 | 6 | 12:18 | -6 | 13 |
| 14 |
|
Inegölspor | 11 | 3 | 3 | 5 | 15:20 | -5 | 12 |
| 15 |
|
Turgutluspor | 11 | 2 | 4 | 5 | 13:19 | -6 | 10 |
| 16 |
|
Sarıyer SK | 11 | 3 | 1 | 7 | 11:19 | -8 | 10 |
| 17 |
|
Ergene Velimeşe | 11 | 3 | 1 | 7 | 9:24 | -15 | 10 |
| 18 |
|
Niğde Anadolu FK | 11 | 1 | 2 | 8 | 5:27 | -22 | 5 |
| 19 |
|
Adıyamanspor | 11 | 1 | 0 | 10 | 9:23 | -14 | 3 |
| 20 |
|
Kahramanmaraşspor | 11 | 0 | 0 | 11 | 4:31 | -27 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
