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| 09.04.2022 | 14:00 | Pazarspor | - | Tarsus Idman Yurdu | 0:1 (0:1) | |
| 14:00 | Zonguldak Kömürspor | - | Bucaspor 1928 | 1:1 (0:0) | ||
| 10.04.2022 | Kastamonuspor | - | 1922 Konyaspor | pas disputer | ||
| 14:00 | Amed SK | - | 24 Erzincanspor | 3:1 (2:0) | ||
| 14:00 | Ankara Demirspor | - | Kırşehir Belediyespor | 2:3 (0:0) | ||
| 14:00 | Eskişehirspor | - | Uşakspor | 1:1 (0:0) | ||
| 14:00 | Karacabey Belediyespor | - | Pendikspor | 1:2 (0:0) | ||
| 14:00 | Kırklarelispor | - | Isparta 32 SK | 1:1 (0:1) | ||
| 14:00 | Şanlıurfaspor | - | Akhisar Belediyespor | 4:0 (3:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pendikspor | 30 | 21 | 4 | 5 | 47:23 | 24 | 67 |
| 2 |
|
Amed SK | 30 | 14 | 8 | 8 | 40:32 | 8 | 50 |
| 3 |
|
Tarsus Idman Yurdu | 31 | 14 | 7 | 10 | 38:30 | 8 | 49 |
| 4 |
|
Isparta 32 SK | 31 | 14 | 7 | 10 | 35:27 | 8 | 49 |
| 5 |
|
Bucaspor 1928 | 31 | 13 | 8 | 10 | 47:39 | 8 | 47 |
| 6 |
|
Kırklarelispor | 30 | 11 | 12 | 7 | 37:25 | 12 | 45 |
| 7 |
|
24 Erzincanspor | 31 | 13 | 6 | 12 | 51:41 | 10 | 45 |
| 8 |
|
Ankara Demirspor | 31 | 12 | 9 | 10 | 37:31 | 6 | 45 |
| 9 |
|
Karacabey Belediyespor | 30 | 14 | 2 | 14 | 46:39 | 7 | 44 |
| 10 |
|
Nazilli Belediyespor | 30 | 10 | 11 | 9 | 29:29 | 0 | 41 |
| 11 |
|
Şanlıurfaspor | 30 | 10 | 10 | 10 | 41:34 | 7 | 40 |
| 12 |
|
Kırşehir Belediyespor | 30 | 9 | 13 | 8 | 33:28 | 5 | 40 |
| 13 |
|
Uşakspor | 30 | 9 | 11 | 10 | 28:38 | -10 | 38 |
| 14 |
|
Zonguldak Kömürspor | 30 | 8 | 11 | 11 | 33:39 | -6 | 35 |
| 15 |
|
Pazarspor | 30 | 10 | 2 | 18 | 33:55 | -22 | 32 |
| 16 |
|
1922 Konyaspor | 31 | 6 | 11 | 14 | 36:47 | -11 | 29 |
| 17 |
|
Akhisar Belediyespor | 31 | 8 | 5 | 18 | 32:53 | -21 | 29 |
| 18 |
|
Eskişehirspor | 31 | 6 | 7 | 18 | 28:61 | -33 | 22 |
| 19 |
|
Kastamonuspor | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
