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| 19.03.2022 | 12:00 | Şanlıurfaspor | - | 1922 Konyaspor | 2:2 (0:2) | |
| 20.03.2022 | 11:00 | Kırşehir Belediyespor | - | Pendikspor | 0:1 (0:0) | |
| 11:55 | Nazilli Belediyespor | - | Akhisar Belediyespor | 3:1 (1:0) | ||
| 12:00 | Amed SK | - | Kastamonuspor | pas disputer | ||
| 12:00 | Ankara Demirspor | - | Isparta 32 SK | 2:1 (0:1) | ||
| 12:00 | Eskişehirspor | - | Tarsus Idman Yurdu | 1:5 (1:3) | ||
| 12:00 | Karacabey Belediyespor | - | 24 Erzincanspor | 3:0 (2:0) | ||
| 12:00 | Kırklarelispor | - | Bucaspor 1928 | 2:0 (0:0) | ||
| 13.04.2022 | 13:00 | Pazarspor | - | Zonguldak Kömürspor | 2:2 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pendikspor | 26 | 19 | 3 | 4 | 41:19 | 22 | 60 |
| 2 |
|
Isparta 32 SK | 27 | 13 | 5 | 9 | 32:25 | 7 | 44 |
| 3 |
|
Bucaspor 1928 | 28 | 12 | 6 | 10 | 41:36 | 5 | 42 |
| 4 |
|
Amed SK | 26 | 12 | 6 | 8 | 31:27 | 4 | 42 |
| 5 |
|
Ankara Demirspor | 27 | 11 | 8 | 8 | 32:25 | 7 | 41 |
| 6 |
|
Karacabey Belediyespor | 26 | 13 | 1 | 12 | 39:35 | 4 | 40 |
| 7 |
|
24 Erzincanspor | 27 | 11 | 6 | 10 | 44:35 | 9 | 39 |
| 8 |
|
Kırklarelispor | 26 | 9 | 11 | 6 | 32:22 | 10 | 38 |
| 9 |
|
Tarsus Idman Yurdu | 27 | 10 | 7 | 10 | 31:28 | 3 | 37 |
| 10 |
|
Nazilli Belediyespor | 27 | 9 | 10 | 8 | 26:26 | 0 | 37 |
| 11 |
|
Kırşehir Belediyespor | 27 | 8 | 11 | 8 | 29:25 | 4 | 35 |
| 12 |
|
Şanlıurfaspor | 26 | 8 | 10 | 8 | 34:30 | 4 | 34 |
| 13 |
|
Zonguldak Kömürspor | 28 | 8 | 10 | 10 | 31:35 | -4 | 34 |
| 14 |
|
Uşakspor | 26 | 8 | 9 | 9 | 26:35 | -9 | 33 |
| 15 |
|
Pazarspor | 26 | 9 | 2 | 15 | 29:45 | -16 | 29 |
| 16 |
|
1922 Konyaspor | 28 | 6 | 10 | 12 | 33:41 | -8 | 28 |
| 17 |
|
Akhisar Belediyespor | 27 | 7 | 5 | 15 | 29:41 | -12 | 26 |
| 18 |
|
Eskişehirspor | 27 | 5 | 6 | 16 | 25:55 | -30 | 18 |
| 19 |
|
Kastamonuspor | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
