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| 05.03.2022 | 12:00 | 1922 Konyaspor | - | Karacabey Belediyespor | 0:1 (0:1) | |
| 12:00 | Bucaspor 1928 | - | Şanlıurfaspor | 1:2 (1:0) | ||
| 12:00 | 24 Erzincanspor | - | Eskişehirspor | 4:0 (1:0) | ||
| 12:00 | Akhisar Belediyespor | - | Kırşehir Belediyespor | 1:0 (0:0) | ||
| 12:00 | Isparta 32 SK | - | Nazilli Belediyespor | 1:0 (0:0) | ||
| 12:00 | Pendikspor | - | Uşakspor | 4:0 (2:0) | ||
| 12:00 | Tarsus Idman Yurdu | - | Ankara Demirspor | 2:1 (1:0) | ||
| 12:00 | Zonguldak Kömürspor | - | Kırklarelispor | 1:0 (0:0) | ||
| 06.03.2022 | Kastamonuspor | - | Pazarspor | pas disputer |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pendikspor | 25 | 18 | 3 | 4 | 40:19 | 21 | 57 |
| 2 |
|
Isparta 32 SK | 26 | 13 | 5 | 8 | 31:23 | 8 | 44 |
| 3 |
|
Bucaspor 1928 | 27 | 12 | 6 | 9 | 41:34 | 7 | 42 |
| 4 |
|
Amed SK | 26 | 12 | 6 | 8 | 31:27 | 4 | 42 |
| 5 |
|
24 Erzincanspor | 26 | 11 | 6 | 9 | 44:32 | 12 | 39 |
| 6 |
|
Ankara Demirspor | 26 | 10 | 8 | 8 | 30:24 | 6 | 38 |
| 7 |
|
Karacabey Belediyespor | 25 | 12 | 1 | 12 | 36:35 | 1 | 37 |
| 8 |
|
Kırklarelispor | 25 | 8 | 11 | 6 | 30:22 | 8 | 35 |
| 9 |
|
Kırşehir Belediyespor | 26 | 8 | 11 | 7 | 29:24 | 5 | 35 |
| 10 |
|
Tarsus Idman Yurdu | 26 | 9 | 7 | 10 | 26:27 | -1 | 34 |
| 11 |
|
Nazilli Belediyespor | 26 | 8 | 10 | 8 | 23:25 | -2 | 34 |
| 12 |
|
Şanlıurfaspor | 25 | 8 | 9 | 8 | 32:28 | 4 | 33 |
| 13 |
|
Zonguldak Kömürspor | 27 | 8 | 9 | 10 | 29:33 | -4 | 33 |
| 14 |
|
Uşakspor | 26 | 8 | 9 | 9 | 26:35 | -9 | 33 |
| 15 |
|
Pazarspor | 25 | 9 | 1 | 15 | 27:43 | -16 | 28 |
| 16 |
|
1922 Konyaspor | 27 | 6 | 9 | 12 | 31:39 | -8 | 27 |
| 17 |
|
Akhisar Belediyespor | 26 | 7 | 5 | 14 | 28:38 | -10 | 26 |
| 18 |
|
Eskişehirspor | 26 | 5 | 6 | 15 | 24:50 | -26 | 18 |
| 19 |
|
Kastamonuspor | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
