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| 12.02.2022 | 11:00 | Bucaspor 1928 | - | Nazilli Belediyespor | 1:1 (0:0) | |
| 13.02.2022 | Kastamonuspor | - | Eskişehirspor | pas disputer | ||
| 11:00 | 1922 Konyaspor | - | Kırşehir Belediyespor | 1:2 (0:1) | ||
| 11:00 | 24 Erzincanspor | - | Uşakspor | 1:2 (0:0) | ||
| 11:00 | Amed SK | - | Karacabey Belediyespor | 0:1 (0:1) | ||
| 11:00 | Isparta 32 SK | - | Akhisar Belediyespor | 2:1 (0:1) | ||
| 11:00 | Pazarspor | - | Şanlıurfaspor | 0:5 (0:2) | ||
| 11:00 | Tarsus Idman Yurdu | - | Pendikspor | 1:3 (1:1) | ||
| 11:00 | Zonguldak Kömürspor | - | Ankara Demirspor | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pendikspor | 22 | 16 | 3 | 3 | 35:18 | 17 | 51 |
| 2 |
|
Bucaspor 1928 | 23 | 11 | 5 | 7 | 36:29 | 7 | 38 |
| 3 |
|
Isparta 32 SK | 22 | 10 | 4 | 8 | 25:20 | 5 | 34 |
| 4 |
|
Kırşehir Belediyespor | 22 | 8 | 9 | 5 | 26:19 | 7 | 33 |
| 5 |
|
Nazilli Belediyespor | 22 | 8 | 9 | 5 | 20:17 | 3 | 33 |
| 6 |
|
Amed SK | 23 | 9 | 6 | 8 | 27:26 | 1 | 33 |
| 7 |
|
Kırklarelispor | 22 | 7 | 11 | 4 | 29:20 | 9 | 32 |
| 8 |
|
24 Erzincanspor | 22 | 9 | 5 | 8 | 36:28 | 8 | 32 |
| 9 |
|
Ankara Demirspor | 22 | 8 | 7 | 7 | 24:21 | 3 | 31 |
| 10 |
|
Şanlıurfaspor | 22 | 7 | 8 | 7 | 28:24 | 4 | 29 |
| 11 |
|
Uşakspor | 22 | 7 | 8 | 7 | 21:26 | -5 | 29 |
| 12 |
|
Karacabey Belediyespor | 22 | 9 | 1 | 12 | 33:35 | -2 | 28 |
| 13 |
|
Zonguldak Kömürspor | 23 | 7 | 7 | 9 | 27:31 | -4 | 28 |
| 14 |
|
Pazarspor | 23 | 9 | 1 | 13 | 27:41 | -14 | 28 |
| 15 |
|
Tarsus Idman Yurdu | 22 | 6 | 6 | 10 | 19:24 | -5 | 24 |
| 16 |
|
1922 Konyaspor | 23 | 5 | 8 | 10 | 27:33 | -6 | 23 |
| 17 |
|
Akhisar Belediyespor | 23 | 6 | 5 | 12 | 26:35 | -9 | 23 |
| 18 |
|
Eskişehirspor | 22 | 5 | 5 | 12 | 22:41 | -19 | 17 |
| 19 |
|
Kastamonuspor | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
