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| 15.04.2022 | 13:30 | Keçiörengücü | - | Denizlispor | 0:1 (0:0) | |
| 16:00 | Tuzlaspor | - | Gençlerbirliği | 4:0 (4:0) | ||
| 19:30 | İstanbulspor AŞ | - | Bursaspor | 3:1 (1:1) | ||
| 16.04.2022 | 12:30 | Balıkesirspor | - | Menemen Belediyespor | 1:1 (1:0) | |
| 15:00 | Altınordu FK | - | Manisa FK | 1:0 (1:0) | ||
| 15:00 | Kocaelispor | - | Bandırmaspor | 2:1 (0:1) | ||
| 19:30 | Boluspor | - | BB Erzurumspor | 0:2 (0:1) | ||
| 17.04.2022 | 15:00 | MKE Ankaragücü | - | Adanaspor | 2:0 (1:0) | |
| 19:30 | Samsunspor | - | Eyüpspor | 2:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 31 | 19 | 6 | 6 | 49:25 | 24 | 63 |
| 2 |
|
Ümraniyespor | 30 | 17 | 6 | 7 | 50:30 | 20 | 57 |
| 3 |
|
Bandırmaspor | 31 | 17 | 4 | 10 | 47:27 | 20 | 55 |
| 4 |
|
İstanbulspor AŞ | 30 | 16 | 6 | 8 | 50:32 | 18 | 54 |
| 5 |
|
Eyüpspor | 31 | 13 | 12 | 6 | 48:36 | 12 | 51 |
| 6 |
|
BB Erzurumspor | 30 | 14 | 8 | 8 | 48:34 | 14 | 50 |
| 7 |
|
Samsunspor | 30 | 11 | 10 | 9 | 47:40 | 7 | 43 |
| 8 |
|
Manisa FK | 31 | 12 | 7 | 12 | 35:36 | -1 | 43 |
| 9 |
|
Tuzlaspor | 30 | 11 | 8 | 11 | 33:31 | 2 | 41 |
| 10 |
|
Adanaspor | 31 | 11 | 8 | 12 | 35:33 | 2 | 41 |
| 11 |
|
Keçiörengücü | 30 | 10 | 8 | 12 | 36:40 | -4 | 38 |
| 12 |
|
Gençlerbirliği | 30 | 11 | 5 | 14 | 34:46 | -12 | 38 |
| 13 |
|
Altınordu FK | 31 | 12 | 2 | 17 | 36:53 | -17 | 38 |
| 14 |
|
Menemen Belediyespor | 30 | 8 | 12 | 10 | 38:48 | -10 | 36 |
| 15 |
|
Denizlispor | 30 | 10 | 6 | 14 | 34:44 | -10 | 36 |
| 16 |
|
Kocaelispor | 30 | 10 | 6 | 14 | 30:41 | -11 | 36 |
| 17 |
|
Boluspor | 30 | 9 | 8 | 13 | 32:38 | -6 | 35 |
| 18 |
|
Bursaspor | 30 | 8 | 7 | 15 | 33:46 | -13 | 31 |
| 19 |
|
Balıkesirspor | 30 | 3 | 3 | 24 | 23:58 | -35 | 12 |
| Promotion | |
| Play-off | |
| Relégation |
