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| 19.02.2022 | 11:30 | Boluspor | - | Gençlerbirliği | 3:1 (1:0) | |
| 17:00 | Tuzlaspor | - | Kocaelispor | 0:0 (0:0) | ||
| 20.02.2022 | 11:30 | Samsunspor | - | Denizlispor | 5:0 (3:0) | |
| 14:00 | Balıkesirspor | - | İstanbulspor AŞ | 1:3 (0:0) | ||
| 17:00 | MKE Ankaragücü | - | Bursaspor | 2:1 (0:1) | ||
| 21.02.2022 | 12:30 | Manisa FK | - | Ümraniyespor | 2:1 (1:1) | |
| 15:00 | Adanaspor | - | BB Erzurumspor | 1:1 (0:0) | ||
| 18:00 | Altınordu FK | - | Bandırmaspor | 0:2 (0:1) | ||
| 18:00 | Eyüpspor | - | Menemen Belediyespor | 1:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 25 | 16 | 4 | 5 | 40:19 | 21 | 52 |
| 2 |
|
Ümraniyespor | 25 | 15 | 4 | 6 | 43:25 | 18 | 49 |
| 3 |
|
Eyüpspor | 25 | 12 | 9 | 4 | 39:26 | 13 | 45 |
| 4 |
|
BB Erzurumspor | 25 | 12 | 8 | 5 | 40:29 | 11 | 44 |
| 5 |
|
Bandırmaspor | 25 | 13 | 4 | 8 | 38:23 | 15 | 43 |
| 6 |
|
İstanbulspor AŞ | 24 | 13 | 3 | 8 | 40:28 | 12 | 42 |
| 7 |
|
Samsunspor | 24 | 10 | 9 | 5 | 40:27 | 13 | 39 |
| 8 |
|
Boluspor | 24 | 9 | 7 | 8 | 28:25 | 3 | 34 |
| 9 |
|
Tuzlaspor | 24 | 9 | 7 | 8 | 23:22 | 1 | 34 |
| 10 |
|
Adanaspor | 25 | 9 | 7 | 9 | 29:26 | 3 | 34 |
| 11 |
|
Manisa FK | 25 | 9 | 6 | 10 | 28:30 | -2 | 33 |
| 12 |
|
Keçiörengücü | 24 | 8 | 7 | 9 | 32:34 | -2 | 31 |
| 13 |
|
Gençlerbirliği | 25 | 9 | 3 | 13 | 29:41 | -12 | 30 |
| 14 |
|
Menemen Belediyespor | 25 | 6 | 11 | 8 | 29:39 | -10 | 29 |
| 15 |
|
Kocaelispor | 24 | 8 | 4 | 12 | 23:31 | -8 | 28 |
| 16 |
|
Bursaspor | 25 | 6 | 6 | 13 | 26:38 | -12 | 24 |
| 17 |
|
Denizlispor | 25 | 6 | 6 | 13 | 23:39 | -16 | 24 |
| 18 |
|
Altınordu FK | 25 | 7 | 1 | 17 | 28:51 | -23 | 22 |
| 19 |
|
Balıkesirspor | 24 | 3 | 2 | 19 | 19:44 | -25 | 11 |
| Promotion | |
| Play-off | |
| Relégation |
