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| 11.02.2022 | 14:00 | Altınordu FK | - | Gençlerbirliği | 1:2 (1:1) | |
| 17:00 | Samsunspor | - | Bursaspor | 1:1 (1:0) | ||
| 12.02.2022 | 11:30 | Adanaspor | - | Denizlispor | 0:0 (0:0) | |
| 11:30 | Boluspor | - | Keçiörengücü | 0:0 (0:0) | ||
| 14:00 | MKE Ankaragücü | - | İstanbulspor AŞ | 0:1 (0:1) | ||
| 17:00 | Balıkesirspor | - | Kocaelispor | 1:2 (1:0) | ||
| 13.02.2022 | 11:30 | Manisa FK | - | Menemen Belediyespor | 1:1 (0:0) | |
| 11:30 | Ümraniyespor | - | BB Erzurumspor | 3:3 (2:1) | ||
| 17:00 | Eyüpspor | - | Bandırmaspor | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 23 | 15 | 3 | 5 | 37:17 | 20 | 48 |
| 2 |
|
Ümraniyespor | 23 | 14 | 4 | 5 | 40:22 | 18 | 46 |
| 3 |
|
Eyüpspor | 23 | 12 | 7 | 4 | 37:24 | 13 | 43 |
| 4 |
|
BB Erzurumspor | 23 | 12 | 6 | 5 | 38:27 | 11 | 42 |
| 5 |
|
Bandırmaspor | 23 | 12 | 3 | 8 | 36:23 | 13 | 39 |
| 6 |
|
İstanbulspor AŞ | 22 | 12 | 3 | 7 | 36:25 | 11 | 39 |
| 7 |
|
Samsunspor | 22 | 9 | 8 | 5 | 33:25 | 8 | 35 |
| 8 |
|
Adanaspor | 23 | 9 | 6 | 8 | 27:23 | 4 | 33 |
| 9 |
|
Tuzlaspor | 22 | 8 | 6 | 8 | 22:22 | 0 | 30 |
| 10 |
|
Manisa FK | 23 | 8 | 5 | 10 | 26:29 | -3 | 29 |
| 11 |
|
Gençlerbirliği | 23 | 9 | 2 | 12 | 26:36 | -10 | 29 |
| 12 |
|
Boluspor | 22 | 7 | 7 | 8 | 23:23 | 0 | 28 |
| 13 |
|
Keçiörengücü | 23 | 7 | 7 | 9 | 29:33 | -4 | 28 |
| 14 |
|
Kocaelispor | 23 | 8 | 3 | 12 | 23:31 | -8 | 27 |
| 15 |
|
Menemen Belediyespor | 23 | 6 | 9 | 8 | 27:37 | -10 | 27 |
| 16 |
|
Bursaspor | 23 | 6 | 6 | 11 | 25:35 | -10 | 24 |
| 17 |
|
Altınordu FK | 23 | 7 | 1 | 15 | 28:48 | -20 | 22 |
| 18 |
|
Denizlispor | 23 | 5 | 6 | 12 | 22:34 | -12 | 21 |
| 19 |
|
Balıkesirspor | 22 | 3 | 2 | 17 | 17:38 | -21 | 11 |
| Promotion | |
| Play-off | |
| Relégation |
