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| 24.12.2021 | 14:30 | Altınordu FK | - | Boluspor | 2:1 (1:1) | |
| 17:00 | Adanaspor | - | Kocaelispor | 2:0 (1:0) | ||
| 25.12.2021 | 11:30 | Bandırmaspor | - | İstanbulspor AŞ | 0:0 (0:0) | |
| 11:30 | BB Erzurumspor | - | Denizlispor | 3:1 (0:0) | ||
| 17:00 | Menemen Belediyespor | - | Bursaspor | 0:0 (0:0) | ||
| 26.12.2021 | 11:30 | Ümraniyespor | - | Gençlerbirliği | 3:1 (2:0) | |
| 14:00 | Samsunspor | - | Tuzlaspor | 2:2 (1:1) | ||
| 17:00 | MKE Ankaragücü | - | Keçiörengücü | 2:1 (1:1) | ||
| 17:00 | Eyüpspor | - | Balıkesirspor | 1:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Ümraniyespor | 18 | 12 | 3 | 3 | 34:15 | 19 | 39 |
| 2 |
|
BB Erzurumspor | 18 | 11 | 3 | 4 | 32:21 | 11 | 36 |
| 3 |
|
MKE Ankaragücü | 18 | 11 | 3 | 4 | 29:14 | 15 | 36 |
| 4 |
|
Bandırmaspor | 18 | 10 | 2 | 6 | 28:15 | 13 | 32 |
| 5 |
|
Eyüpspor | 18 | 9 | 5 | 4 | 29:22 | 7 | 32 |
| 6 |
|
İstanbulspor AŞ | 18 | 8 | 3 | 7 | 27:24 | 3 | 27 |
| 7 |
|
Samsunspor | 18 | 7 | 6 | 5 | 26:23 | 3 | 27 |
| 8 |
|
Gençlerbirliği | 18 | 8 | 2 | 8 | 23:25 | -2 | 26 |
| 9 |
|
Adanaspor | 18 | 7 | 5 | 6 | 20:19 | 1 | 26 |
| 10 |
|
Tuzlaspor | 18 | 6 | 6 | 6 | 19:18 | 1 | 24 |
| 11 |
|
Kocaelispor | 18 | 7 | 3 | 8 | 19:22 | -3 | 24 |
| 12 |
|
Manisa FK | 18 | 6 | 4 | 8 | 20:24 | -4 | 22 |
| 13 |
|
Altınordu FK | 18 | 7 | 1 | 10 | 24:35 | -11 | 22 |
| 14 |
|
Boluspor | 18 | 5 | 6 | 7 | 20:21 | -1 | 21 |
| 15 |
|
Menemen Belediyespor | 18 | 5 | 6 | 7 | 21:31 | -10 | 21 |
| 16 |
|
Keçiörengücü | 18 | 5 | 4 | 9 | 24:30 | -6 | 19 |
| 17 |
|
Bursaspor | 18 | 5 | 4 | 9 | 22:28 | -6 | 19 |
| 18 |
|
Denizlispor | 18 | 4 | 4 | 10 | 15:26 | -11 | 16 |
| 19 |
|
Balıkesirspor | 18 | 2 | 2 | 14 | 14:33 | -19 | 8 |
| Promotion | |
| Play-off | |
| Relégation |
