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| 10.12.2021 | 18:00 | Gençlerbirliği | - | Denizlispor | 1:0 (0:0) | |
| 18:00 | Kocaelispor | - | BB Erzurumspor | 2:0 (1:0) | ||
| 11.12.2021 | 11:30 | Boluspor | - | Adanaspor | 0:0 (0:0) | |
| 11:30 | Keçiörengücü | - | Bandırmaspor | 3:2 (1:1) | ||
| 14:00 | Tuzlaspor | - | Menemen Belediyespor | 1:1 (0:1) | ||
| 17:00 | Balıkesirspor | - | Ümraniyespor | 1:2 (0:1) | ||
| 17:00 | Bursaspor | - | Manisa FK | 1:1 (0:0) | ||
| 17:00 | İstanbulspor AŞ | - | Eyüpspor | 2:1 (0:0) | ||
| 12.12.2021 | 17:00 | Samsunspor | - | MKE Ankaragücü | 2:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 16 | 9 | 3 | 4 | 25:13 | 12 | 30 |
| 2 |
|
Ümraniyespor | 15 | 9 | 3 | 3 | 26:13 | 13 | 30 |
| 3 |
|
BB Erzurumspor | 15 | 9 | 2 | 4 | 24:17 | 7 | 29 |
| 4 |
|
Eyüpspor | 15 | 8 | 3 | 4 | 25:20 | 5 | 27 |
| 5 |
|
Bandırmaspor | 15 | 8 | 1 | 6 | 24:15 | 9 | 25 |
| 6 |
|
Samsunspor | 15 | 7 | 4 | 4 | 22:18 | 4 | 25 |
| 7 |
|
Tuzlaspor | 15 | 6 | 5 | 4 | 17:13 | 4 | 23 |
| 8 |
|
İstanbulspor AŞ | 15 | 7 | 2 | 6 | 25:22 | 3 | 23 |
| 9 |
|
Kocaelispor | 15 | 7 | 2 | 6 | 16:16 | 0 | 23 |
| 10 |
|
Gençlerbirliği | 15 | 7 | 2 | 6 | 17:20 | -3 | 23 |
| 11 |
|
Boluspor | 15 | 5 | 5 | 5 | 18:16 | 2 | 20 |
| 12 |
|
Adanaspor | 16 | 5 | 5 | 6 | 17:19 | -2 | 20 |
| 13 |
|
Menemen Belediyespor | 15 | 5 | 4 | 6 | 21:26 | -5 | 19 |
| 14 |
|
Bursaspor | 15 | 5 | 3 | 7 | 21:23 | -2 | 18 |
| 15 |
|
Manisa FK | 16 | 5 | 3 | 8 | 18:23 | -5 | 18 |
| 16 |
|
Keçiörengücü | 15 | 5 | 2 | 8 | 19:24 | -5 | 17 |
| 17 |
|
Denizlispor | 15 | 4 | 3 | 8 | 14:22 | -8 | 15 |
| 18 |
|
Altınordu FK | 15 | 4 | 1 | 10 | 15:29 | -14 | 13 |
| 19 |
|
Balıkesirspor | 15 | 2 | 1 | 12 | 10:25 | -15 | 7 |
| Promotion | |
| Play-off | |
| Relégation |
