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| 11.10.2022 | 15:30 | FC Košice | - | KFC Komárno | 2:3 (1:1) | |
| 18.10.2022 | 14:30 | FK Pohronie | - | Tatran Liptovský Mikuláš | 0:1 (0:1) | |
| 14:30 | FK Humenné | - | FC DAC 1904 | 2:1 (0:1) | ||
| 14:30 | 1. MFK Kežmarok | - | Dukla Banská Bystrica | 0:1 (0:1) | ||
| 14:30 | FK MŠK Považská Bystrica | - | Zlaté Moravce | 7:8 (0:0, 2:2) tab | ||
| 19.10.2022 | 14:30 | 1. FC Tatran Prešov | - | FK Železiarne Podbrezová | 1:0 (1:0) | |
| 14:30 | OK Častkovce | - | TJ Jednota Bánová | 1:2 (0:2) | ||
| 14:30 | FK Slavoj Trebišov | - | AS Trenčín | 0:4 (0:1) | ||
| 14:30 | FK Brezno | - | MŠK Púchov | 1:3 (0:2) | ||
| 14:30 | ŠTK 1914 Šamorín | - | MŠK Žilina | 2:1 (0:0) | ||
| 15:00 | Lokomotíva DNV | - | MFK Ružomberok | 0:3 (0:1) | ||
| 19:00 | Spartak Myjava | - | MFK Dolný Kubín | 4:1 (2:1) | ||
| 25.10.2022 | 14:30 | MFK Dubnica | - | MFK Zemplín Michalovce | 0:3 (0:2) | |
| 14:30 | SK Odeva Lipany | - | MFK Skalica | 0:1 (0:1) | ||
| 26.10.2022 | 14:30 | ŠKF Sereď | - | Spartak Trnava | 0:3 (0:1) | |
| 09.11.2022 | 13:00 | MŠK Tesla Stropkov | - | Slovan Bratislava | 2:3 (0:3) |
