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| H (Match allé) | FC Winterthur | - | FC Basel 1893 | 1:2 (1:1) | ||
| R (match retour) | FC Basel 1893 | - | FC Winterthur | 3:0 (1:0) | ||
| H (Match allé): 28.05.2022 13:00 | R (match retour): 04.06.2022 16:30 | vainqueur: FC Basel 1893 | ||||
| H (Match allé) | FC Zürich | - | Team Vaud Lausanne | 5:0 (2:0) | ||
| R (match retour) | Team Vaud Lausanne | - | FC Zürich | 2:3 (0:2) | ||
| H (Match allé): 28.05.2022 14:00 | R (match retour): 04.06.2022 14:30 | vainqueur: FC Zürich | ||||
| H (Match allé) | FCO St. Gallen/Wil | - | Servette FC | 2:1 (1:0) | ||
| R (match retour) | Servette FC | - | FCO St. Gallen/Wil | 3:1 (0:0) | ||
| H (Match allé): 28.05.2022 14:00 | R (match retour): 04.06.2022 14:00 | vainqueur: Servette FC | ||||
| H (Match allé) | Team Aargau | - | BSC Young Boys | 1:5 (0:3) | ||
| R (match retour) | BSC Young Boys | - | Team Aargau | 3:0 (1:0) | ||
| H (Match allé): 28.05.2022 16:00 | R (match retour): 04.06.2022 14:00 | vainqueur: BSC Young Boys | ||||
