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| 17.09.2021 | 19:30 | FC Bulle | - | FC Lausanne-Sport | 2:3 (0:2, 2:2) ap | |
| 19:30 | SC Kriens | - | FC Zürich | 0:1 (0:1) | ||
| 20:00 | FC Concordia Basel | - | Servette FC | 1:4 (1:1) | ||
| 20:00 | Neuchâtel Xamax FCS | - | FC Lugano | 0:1 (0:0) | ||
| 20:00 | Yverdon Sport FC | - | FC Wil 1900 | 3:0 (2:0) | ||
| 18.09.2021 | 15:00 | FC Black Stars Basel | - | FC Biel/Bienne | 1:3 (0:0) | |
| 17:00 | Stade Lausanne-Ouchy | - | FC Sion | 4:0 (2:0) | ||
| 18:00 | FC Paradiso | - | FC Aarau | 0:1 (0:0) | ||
| 18:00 | Etoile Carouge FC | - | FC Winterthur | 3:1 (2:1) | ||
| 18:00 | SC Buochs | - | FC Luzern | 1:2 (0:1, 1:1) ap | ||
| 19:00 | FC Bosporus | - | FC Schaffhausen | 0:11 (0:4) | ||
| 20:15 | FC Thun | - | Grasshopper Club Zürich | 1:0 (0:0) | ||
| 19.09.2021 | 14:30 | FC Rorschach-Goldach | - | FC Basel 1893 | 0:3 (0:1) | |
| 15:00 | CS Chênois | - | FC St. Gallen | 2:7 (0:4) | ||
| 16:00 | Iliria Solothurn | - | BSC Young Boys | 1:7 (0:6) | ||
| 16:00 | FC Porrentruy | - | FC Chiasso | 0:3 (0:0) |
