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| 12.02.2022 | 13:00 | FK Radnički 1923 | - | Proleter Novi Sad | 0:1 (0:0) | |
| 14:30 | Radnički Niš | - | Partizan | 0:2 (0:1) | ||
| 17:00 | Crvena Zvezda | - | FK Čukarički | 3:0 (1:0) | ||
| 13.02.2022 | 13:00 | Mladost Lučani | - | TSC Bačka Topola | 2:0 (1:0) | |
| 15:00 | FK Metalac | - | FK Novi Pazar | 1:0 (0:0) | ||
| 17:00 | FK Kolubara | - | FK Voždovac | 1:0 (1:0) | ||
| 14.02.2022 | 13:00 | Spartak Subotica | - | Radnik Surdulica | 0:2 (0:1) | |
| 15:00 | Vojvodina | - | FK Napredak | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 22 | 20 | 2 | 0 | 59:6 | 53 | 62 |
| 2 |
|
Crvena Zvezda | 22 | 18 | 3 | 1 | 53:13 | 40 | 57 |
| 3 |
|
FK Čukarički | 22 | 10 | 8 | 4 | 38:23 | 15 | 38 |
| 4 |
|
Vojvodina | 22 | 9 | 6 | 7 | 30:28 | 2 | 33 |
| 5 |
|
Radnički Niš | 22 | 7 | 9 | 6 | 27:24 | 3 | 30 |
| 6 |
|
FK Napredak | 22 | 9 | 3 | 10 | 26:26 | 0 | 30 |
| 7 |
|
FK Voždovac | 22 | 8 | 5 | 9 | 28:27 | 1 | 29 |
| 8 |
|
Mladost Lučani | 22 | 8 | 3 | 11 | 26:31 | -5 | 27 |
| 9 |
|
Spartak Subotica | 22 | 7 | 6 | 9 | 24:36 | -12 | 27 |
| 10 |
|
Proleter Novi Sad | 22 | 8 | 3 | 11 | 17:34 | -17 | 27 |
| 11 |
|
TSC Bačka Topola | 22 | 7 | 5 | 10 | 34:33 | 1 | 26 |
| 12 |
|
FK Kolubara | 22 | 8 | 2 | 12 | 24:44 | -20 | 26 |
| 13 |
|
Radnik Surdulica | 22 | 5 | 9 | 8 | 18:25 | -7 | 24 |
| 14 |
|
FK Metalac | 22 | 5 | 4 | 13 | 26:41 | -15 | 19 |
| 15 |
|
FK Novi Pazar | 22 | 3 | 8 | 11 | 20:37 | -17 | 17 |
| 16 |
|
FK Radnički 1923 | 22 | 4 | 4 | 14 | 20:42 | -22 | 16 |
| Play-off | |
| Relégation |
