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| 27.11.2021 | 13:00 | FK Radnički 1923 | - | FK Napredak | 1:2 (1:1) | |
| 17:00 | FK Metalac | - | FK Čukarički | 0:3 (0:1) | ||
| 28.11.2021 | 13:00 | FK Kolubara | - | TSC Bačka Topola | 2:1 (0:1) | |
| 13:00 | Radnički Niš | - | Radnik Surdulica | 3:0 (2:0) | ||
| 14:25 | Crvena Zvezda | - | Spartak Subotica | 3:0 (1:0) | ||
| 16:30 | FK Voždovac | - | Partizan | 0:3 (0:1) | ||
| 29.11.2021 | 15:00 | FK Novi Pazar | - | Proleter Novi Sad | 2:0 (2:0) | |
| 17:00 | Vojvodina | - | Mladost Lučani | 3:1 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 18 | 16 | 2 | 0 | 51:6 | 45 | 50 |
| 2 |
|
Crvena Zvezda | 18 | 15 | 2 | 1 | 44:10 | 34 | 47 |
| 3 |
|
FK Čukarički | 18 | 8 | 7 | 3 | 30:19 | 11 | 31 |
| 4 |
|
Vojvodina | 18 | 8 | 5 | 5 | 25:21 | 4 | 29 |
| 5 |
|
FK Napredak | 18 | 8 | 3 | 7 | 23:20 | 3 | 27 |
| 6 |
|
Radnički Niš | 18 | 6 | 7 | 5 | 22:20 | 2 | 25 |
| 7 |
|
Spartak Subotica | 18 | 6 | 5 | 7 | 21:31 | -10 | 23 |
| 8 |
|
TSC Bačka Topola | 18 | 6 | 4 | 8 | 28:27 | 1 | 22 |
| 9 |
|
FK Voždovac | 18 | 6 | 4 | 8 | 20:23 | -3 | 22 |
| 10 |
|
Proleter Novi Sad | 18 | 6 | 3 | 9 | 14:29 | -15 | 21 |
| 11 |
|
FK Kolubara | 18 | 6 | 2 | 10 | 21:37 | -16 | 20 |
| 12 |
|
Radnik Surdulica | 18 | 4 | 7 | 7 | 15:22 | -7 | 19 |
| 13 |
|
Mladost Lučani | 18 | 5 | 2 | 11 | 19:29 | -10 | 17 |
| 14 |
|
FK Metalac | 18 | 4 | 4 | 10 | 23:32 | -9 | 16 |
| 15 |
|
FK Novi Pazar | 18 | 3 | 6 | 9 | 19:33 | -14 | 15 |
| 16 |
|
FK Radnički 1923 | 18 | 4 | 3 | 11 | 20:36 | -16 | 15 |
| Play-off | |
| Relégation |
