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| 14.11.2020 | 14:00 | 1. FC Köln II | - | Wuppertaler SV | 1:0 (0:0) | |
| 14:00 | Bonner SC | - | SV Rödinghausen | 1:0 (1:0) | ||
| 14:00 | Fortuna Düsseldorf II | - | Fortuna Köln | 3:2 (2:1) | ||
| 14:00 | Rot Weiss Ahlen | - | Bor. Mönchengladbach II | 1:2 (1:2) | ||
| 14:00 | SC Wiedenbrück | - | SV Bergisch Gladbach 09 | 4:1 (1:0) | ||
| 14:00 | Sportfreunde Lotte | - | VfB Homberg | 0:2 (0:1) | ||
| 14:00 | SV Lippstadt 08 | - | Preußen Münster | 0:4 (0:2) | ||
| 09.12.2020 | 19:30 | Rot-Weiss Essen | - | SV 19 Straelen | 4:1 (3:0) | |
| 16.12.2020 | 14:00 | Borussia Dortmund II | - | Rot-Weiß Oberhausen | 2:2 (0:1) | |
| 20.02.2021 | 14:00 | FC Wegberg-Beeck | - | Alemannia Aachen | 2:3 (0:2) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 14 | 10 | 4 | 0 | 36:11 | 25 | 34 |
| 2 |
|
Rot-Weiss Essen | 14 | 10 | 4 | 0 | 27:7 | 20 | 34 |
| 3 |
|
Fortuna Düsseldorf II | 14 | 8 | 5 | 1 | 30:9 | 21 | 29 |
| 4 |
|
Preußen Münster | 14 | 9 | 2 | 3 | 24:11 | 13 | 29 |
| 5 |
|
Fortuna Köln | 14 | 7 | 4 | 3 | 30:18 | 12 | 25 |
| 6 |
|
Bor. Mönchengladbach II | 14 | 7 | 2 | 5 | 26:20 | 6 | 23 |
| 7 |
|
1. FC Köln II | 14 | 6 | 5 | 3 | 20:15 | 5 | 23 |
| 8 |
|
Alemannia Aachen | 15 | 6 | 4 | 5 | 13:12 | 1 | 22 |
| 9 |
|
FC Schalke 04 II | 14 | 5 | 6 | 3 | 16:11 | 5 | 21 |
| 10 |
|
SV Rödinghausen | 15 | 5 | 5 | 5 | 17:15 | 2 | 20 |
| 11 |
|
SV 19 Straelen | 15 | 5 | 5 | 5 | 19:21 | -2 | 20 |
| 12 |
|
FC Wegberg-Beeck | 14 | 4 | 4 | 6 | 16:19 | -3 | 16 |
| 13 |
|
SC Wiedenbrück | 14 | 3 | 7 | 4 | 23:27 | -4 | 16 |
| 14 |
|
Rot-Weiß Oberhausen | 14 | 3 | 6 | 5 | 20:24 | -4 | 15 |
| 15 |
|
Wuppertaler SV | 15 | 4 | 3 | 8 | 15:24 | -9 | 15 |
| 16 |
|
SV Bergisch Gladbach 09 | 15 | 3 | 5 | 7 | 14:24 | -10 | 14 |
| 17 |
|
VfB Homberg | 15 | 4 | 1 | 10 | 14:28 | -14 | 13 |
| 18 |
|
Bonner SC | 14 | 3 | 2 | 9 | 13:28 | -15 | 11 |
| 19 |
|
SV Lippstadt 08 | 14 | 1 | 7 | 6 | 12:25 | -13 | 10 |
| 20 |
|
Sportfreunde Lotte | 14 | 2 | 4 | 8 | 16:33 | -17 | 10 |
| 21 |
|
Rot Weiss Ahlen | 14 | 1 | 3 | 10 | 14:33 | -19 | 6 |
| Promotion | |
| Relégation |
