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| 07.05.2022 | 12:00 | CD Mafra | - | Leixões SC | 0:2 (0:0) | |
| 12:00 | FC Penafiel | - | FC Porto B | 1:2 (0:0) | ||
| 15:00 | SL Benfica B | - | CD Feirense | 1:2 (1:0) | ||
| 15:00 | Sporting Covilhã | - | Rio Ave FC | 0:1 (0:0) | ||
| 16:30 | Casa Pia AC | - | UD Vilafranquense | 2:1 (1:0) | ||
| 16:30 | CD Nacional | - | Académico de Viseu | 1:2 (0:2) | ||
| 08.05.2022 | 12:00 | GD Chaves | - | Estrela Amadora | 2:2 (2:1) | |
| 15:00 | SC Farense | - | Varzim SC | 0:1 (0:1) | ||
| 19:00 | CD Trofense | - | Académica de Coimbra | 2:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Rio Ave FC | 33 | 20 | 7 | 6 | 49:31 | 18 | 67 |
| 2 |
|
Casa Pia AC | 33 | 20 | 5 | 8 | 45:21 | 24 | 65 |
| 3 |
|
GD Chaves | 33 | 18 | 10 | 5 | 54:32 | 22 | 64 |
| 4 |
|
CD Feirense | 33 | 16 | 7 | 10 | 46:36 | 10 | 55 |
| 5 |
|
SL Benfica B | 33 | 16 | 6 | 11 | 58:42 | 16 | 54 |
| 6 |
|
CD Nacional | 33 | 14 | 9 | 10 | 51:40 | 11 | 51 |
| 7 |
|
Leixões SC | 33 | 13 | 9 | 11 | 41:35 | 6 | 48 |
| 8 |
|
FC Penafiel | 33 | 13 | 9 | 11 | 36:37 | -1 | 48 |
| 9 |
|
CD Mafra | 33 | 11 | 10 | 12 | 37:40 | -3 | 43 |
| 10 |
|
FC Porto B | 33 | 10 | 12 | 11 | 43:46 | -3 | 42 |
| 11 |
|
UD Vilafranquense | 33 | 10 | 11 | 12 | 39:43 | -4 | 41 |
| 12 |
|
SC Farense | 33 | 10 | 10 | 13 | 40:42 | -2 | 40 |
| 13 |
|
CD Trofense | 33 | 9 | 10 | 14 | 31:39 | -8 | 37 |
| 14 |
|
Estrela Amadora | 33 | 9 | 10 | 14 | 42:54 | -12 | 37 |
| 15 |
|
Académico de Viseu | 33 | 10 | 7 | 16 | 30:47 | -17 | 37 |
| 16 |
|
Sporting Covilhã | 33 | 7 | 12 | 14 | 29:43 | -14 | 33 |
| 17 |
|
Varzim SC | 33 | 7 | 11 | 15 | 23:39 | -16 | 32 |
| 18 |
|
Académica de Coimbra | 33 | 3 | 7 | 23 | 35:62 | -27 | 16 |
| Promotion | |
| Relégation | |
| Relégation | |
| Relégation |
