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| 29.04.2022 | 19:00 | Académico de Viseu | - | FC Porto B | 1:1 (1:0) | |
| 30.04.2022 | 12:00 | Académica de Coimbra | - | CD Mafra | 0:2 (0:0) | |
| 12:00 | SC Farense | - | GD Chaves | 1:2 (0:1) | ||
| 15:00 | Estrela Amadora | - | FC Penafiel | 0:2 (0:0) | ||
| 16:30 | Leixões SC | - | CD Nacional | 0:1 (0:1) | ||
| 20:15 | Varzim SC | - | Sporting Covilhã | 0:2 (0:0) | ||
| 01.05.2022 | 12:00 | UD Vilafranquense | - | SL Benfica B | 1:2 (1:0) | |
| 13:45 | CD Feirense | - | CD Trofense | 1:2 (0:2) | ||
| 15:00 | Rio Ave FC | - | Casa Pia AC | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Rio Ave FC | 32 | 19 | 7 | 6 | 48:31 | 17 | 64 |
| 2 |
|
GD Chaves | 32 | 18 | 9 | 5 | 52:30 | 22 | 63 |
| 3 |
|
Casa Pia AC | 32 | 19 | 5 | 8 | 43:20 | 23 | 62 |
| 4 |
|
SL Benfica B | 32 | 16 | 6 | 10 | 57:40 | 17 | 54 |
| 5 |
|
CD Feirense | 32 | 15 | 7 | 10 | 44:35 | 9 | 52 |
| 6 |
|
CD Nacional | 32 | 14 | 9 | 9 | 50:38 | 12 | 51 |
| 7 |
|
FC Penafiel | 32 | 13 | 9 | 10 | 35:35 | 0 | 48 |
| 8 |
|
Leixões SC | 32 | 12 | 9 | 11 | 39:35 | 4 | 45 |
| 9 |
|
CD Mafra | 32 | 11 | 10 | 11 | 37:38 | -1 | 43 |
| 10 |
|
UD Vilafranquense | 32 | 10 | 11 | 11 | 38:41 | -3 | 41 |
| 11 |
|
SC Farense | 32 | 10 | 10 | 12 | 40:41 | -1 | 40 |
| 12 |
|
FC Porto B | 32 | 9 | 12 | 11 | 41:45 | -4 | 39 |
| 13 |
|
Estrela Amadora | 32 | 9 | 9 | 14 | 40:52 | -12 | 36 |
| 14 |
|
CD Trofense | 32 | 8 | 10 | 14 | 29:38 | -9 | 34 |
| 15 |
|
Académico de Viseu | 32 | 9 | 7 | 16 | 28:46 | -18 | 34 |
| 16 |
|
Sporting Covilhã | 32 | 7 | 12 | 13 | 29:42 | -13 | 33 |
| 17 |
|
Varzim SC | 32 | 6 | 11 | 15 | 22:39 | -17 | 29 |
| 18 |
|
Académica de Coimbra | 32 | 3 | 7 | 22 | 34:60 | -26 | 16 |
| Promotion | |
| Relégation | |
| Relégation | |
| Relégation |
