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| 04.02.2022 | 19:00 | SL Benfica B | - | Casa Pia AC | 1:1 (1:1) | |
| 05.02.2022 | 16:00 | Académico de Viseu | - | GD Chaves | 0:2 (0:0) | |
| 06.02.2022 | 12:00 | Leixões SC | - | Rio Ave FC | 2:2 (2:0) | |
| 15:00 | UD Vilafranquense | - | CD Mafra | 2:0 (0:0) | ||
| 07.02.2022 | 16:30 | FC Porto B | - | Sporting Covilhã | 3:1 (1:1) | |
| 18:00 | FC Penafiel | - | CD Trofense | 1:0 (0:0) | ||
| 08.02.2022 | 16:30 | Varzim SC | - | CD Nacional | 0:0 (0:0) | |
| 19:00 | CD Feirense | - | SC Farense | 4:1 (1:1) | ||
| 21:15 | Estrela Amadora | - | Académica de Coimbra | 1:3 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Casa Pia AC | 21 | 12 | 4 | 5 | 29:12 | 17 | 40 |
| 2 |
|
SL Benfica B | 21 | 12 | 4 | 5 | 39:23 | 16 | 40 |
| 3 |
|
GD Chaves | 21 | 11 | 6 | 4 | 35:22 | 13 | 39 |
| 4 |
|
CD Feirense | 21 | 12 | 3 | 6 | 34:23 | 11 | 39 |
| 5 |
|
Rio Ave FC | 21 | 11 | 5 | 5 | 36:26 | 10 | 38 |
| 6 |
|
CD Nacional | 21 | 9 | 6 | 6 | 34:27 | 7 | 33 |
| 7 |
|
FC Porto B | 21 | 8 | 7 | 6 | 30:29 | 1 | 31 |
| 8 |
|
FC Penafiel | 21 | 8 | 6 | 7 | 21:23 | -2 | 30 |
| 9 |
|
Estrela Amadora | 21 | 8 | 5 | 8 | 33:38 | -5 | 29 |
| 10 |
|
Leixões SC | 21 | 7 | 5 | 9 | 25:26 | -1 | 26 |
| 11 |
|
CD Mafra | 21 | 6 | 8 | 7 | 21:23 | -2 | 26 |
| 12 |
|
UD Vilafranquense | 21 | 6 | 8 | 7 | 28:31 | -3 | 26 |
| 13 |
|
CD Trofense | 21 | 6 | 7 | 8 | 20:23 | -3 | 25 |
| 14 |
|
SC Farense | 21 | 5 | 8 | 8 | 27:29 | -2 | 23 |
| 15 |
|
Académico de Viseu | 21 | 6 | 5 | 10 | 17:29 | -12 | 23 |
| 16 |
|
Sporting Covilhã | 21 | 3 | 9 | 9 | 17:34 | -17 | 18 |
| 17 |
|
Académica de Coimbra | 21 | 3 | 5 | 13 | 22:35 | -13 | 14 |
| 18 |
|
Varzim SC | 21 | 2 | 7 | 12 | 14:29 | -15 | 13 |
| Promotion | |
| Relégation | |
| Relégation | |
| Relégation |
