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| 05.11.2021 | 19:00 | UD Vilafranquense | - | Estrela Amadora | 2:2 (0:1) | |
| 06.11.2021 | 12:00 | CD Trofense | - | Rio Ave FC | 0:1 (0:1) | |
| 15:00 | Casa Pia AC | - | Académica de Coimbra | 2:0 (1:0) | ||
| 07.11.2021 | 12:00 | FC Penafiel | - | Leixões SC | 1:1 (0:1) | |
| 15:00 | SL Benfica B | - | CD Mafra | 1:3 (1:1) | ||
| 16:30 | FC Porto B | - | Varzim SC | 2:2 (1:0) | ||
| 20:30 | Sporting Covilhã | - | SC Farense | 0:0 (0:0) | ||
| 08.11.2021 | 19:00 | CD Nacional | - | GD Chaves | 1:1 (0:1) | |
| 21:15 | Académico de Viseu | - | CD Feirense | 0:2 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SL Benfica B | 11 | 7 | 2 | 2 | 23:13 | 10 | 23 |
| 2 |
|
CD Feirense | 11 | 7 | 1 | 3 | 17:9 | 8 | 22 |
| 3 |
|
Casa Pia AC | 11 | 6 | 3 | 2 | 18:8 | 10 | 21 |
| 4 |
|
Rio Ave FC | 11 | 6 | 3 | 2 | 22:14 | 8 | 21 |
| 5 |
|
CD Mafra | 11 | 4 | 4 | 3 | 14:11 | 3 | 16 |
| 6 |
|
CD Nacional | 11 | 4 | 4 | 3 | 16:14 | 2 | 16 |
| 7 |
|
Estrela Amadora | 11 | 4 | 4 | 3 | 17:16 | 1 | 16 |
| 8 |
|
FC Penafiel | 11 | 4 | 4 | 3 | 11:11 | 0 | 16 |
| 9 |
|
Académico de Viseu | 11 | 5 | 1 | 5 | 14:19 | -5 | 16 |
| 10 |
|
Leixões SC | 11 | 4 | 3 | 4 | 16:15 | 1 | 15 |
| 11 |
|
FC Porto B | 11 | 3 | 6 | 2 | 15:15 | 0 | 15 |
| 12 |
|
GD Chaves | 11 | 3 | 5 | 3 | 17:15 | 2 | 14 |
| 13 |
|
Sporting Covilhã | 11 | 2 | 6 | 3 | 8:14 | -6 | 12 |
| 14 |
|
CD Trofense | 11 | 2 | 5 | 4 | 8:11 | -3 | 11 |
| 15 |
|
SC Farense | 11 | 1 | 7 | 3 | 13:16 | -3 | 10 |
| 16 |
|
UD Vilafranquense | 11 | 2 | 4 | 5 | 12:18 | -6 | 10 |
| 17 |
|
Varzim SC | 11 | 1 | 4 | 6 | 11:19 | -8 | 7 |
| 18 |
|
Académica de Coimbra | 11 | 0 | 2 | 9 | 9:23 | -14 | 2 |
| Promotion | |
| Relégation | |
| Relégation | |
| Relégation |
