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| 22.01.2022 | 16:00 | FC Porto | - | Leixões SC | 4:1 (2:1) | |
| 16:00 | Paços de Ferreira | - | Sporting Braga | 2:1 (1:1) | ||
| 16:00 | FC Vizela | - | CD Feirense | 3:1 (0:1) | ||
| 16:00 | Vitória Guimarães | - | FC Famalicão | 2:2 (1:1) | ||
| 16:00 | Gil Vicente | - | Rio Ave FC | 1:1 (0:0) | ||
| 16:00 | UD Oliveirense | - | CD Tondela | 0:3 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Porto | 21 | 15 | 3 | 3 | 59:15 | 44 | 48 |
| 2 |
|
Vitória Guimarães | 21 | 12 | 4 | 5 | 42:25 | 17 | 40 |
| 3 |
|
Sporting Braga | 21 | 11 | 5 | 5 | 30:18 | 12 | 38 |
| 4 |
|
Rio Ave FC | 21 | 11 | 3 | 7 | 38:28 | 10 | 36 |
| 5 |
|
FC Famalicão | 21 | 9 | 7 | 5 | 35:24 | 11 | 34 |
| 6 |
|
Paços de Ferreira | 21 | 10 | 3 | 8 | 43:35 | 8 | 33 |
| 7 |
|
Gil Vicente | 21 | 10 | 3 | 8 | 32:30 | 2 | 33 |
| 8 |
|
CD Tondela | 21 | 6 | 9 | 6 | 30:32 | -2 | 27 |
| 9 |
|
FC Vizela | 21 | 7 | 5 | 9 | 30:33 | -3 | 26 |
| 10 |
|
Leixões SC | 21 | 7 | 3 | 11 | 28:38 | -10 | 24 |
| 11 |
|
CD Feirense | 21 | 1 | 5 | 15 | 11:46 | -35 | 8 |
| 12 |
|
UD Oliveirense | 21 | 1 | 2 | 18 | 13:67 | -54 | 5 |
| Play-off | |
| Relégation |
