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| 03.12.2021 | 18:00 | FKS Stal Mielec | - | Wisła Płock | 2:1 (2:0) | |
| 20:30 | Górnik Zabrze | - | Śląsk Wrocław | 3:1 (0:0) | ||
| 04.12.2021 | 15:00 | Bruk-Bet Termalica Nieciecza | - | Pogoń Szczecin | 1:3 (1:2) | |
| 17:30 | Jagiellonia Białystok | - | Górnik Łęczna | 1:2 (0:2) | ||
| 20:00 | Lechia Gdańsk | - | Raków Częstochowa | 3:1 (0:1) | ||
| 05.12.2021 | 17:30 | Zagłębie Lubin | - | Lech Poznań | 2:3 (0:2) | |
| 20:00 | KS Cracovia | - | Legia Warszawa | 1:0 (1:0) | ||
| 06.12.2021 | 18:00 | Warta Poznań | - | Wisła Kraków | 1:1 (0:0) | |
| 14.12.2021 | 18:45 | Radomiak Radom | - | Piast Gliwice | 2:2 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lech Poznań | 17 | 11 | 5 | 1 | 34:10 | 24 | 38 |
| 2 |
|
Pogoń Szczecin | 17 | 10 | 5 | 2 | 32:13 | 19 | 35 |
| 3 |
|
Lechia Gdańsk | 17 | 9 | 6 | 2 | 32:20 | 12 | 33 |
| 4 |
|
Raków Częstochowa | 17 | 8 | 5 | 4 | 30:22 | 8 | 29 |
| 5 |
|
Radomiak Radom | 17 | 7 | 8 | 2 | 23:15 | 8 | 29 |
| 6 |
|
Górnik Zabrze | 17 | 8 | 3 | 6 | 24:22 | 2 | 27 |
| 7 |
|
Śląsk Wrocław | 17 | 6 | 6 | 5 | 29:26 | 3 | 24 |
| 8 |
|
FKS Stal Mielec | 17 | 6 | 6 | 5 | 24:25 | -1 | 24 |
| 9 |
|
Wisła Płock | 17 | 7 | 2 | 8 | 27:26 | 1 | 23 |
| 10 |
|
KS Cracovia | 17 | 6 | 5 | 6 | 23:24 | -1 | 23 |
| 11 |
|
Piast Gliwice | 17 | 6 | 4 | 7 | 25:24 | 1 | 22 |
| 12 |
|
Jagiellonia Białystok | 17 | 5 | 6 | 6 | 22:25 | -3 | 21 |
| 13 |
|
Legia Warszawa | 17 | 6 | 0 | 11 | 23:27 | -4 | 18 |
| 14 |
|
Wisła Kraków | 17 | 5 | 3 | 9 | 17:28 | -11 | 18 |
| 15 |
|
Zagłębie Lubin | 17 | 5 | 2 | 10 | 17:33 | -16 | 17 |
| 16 |
|
Bruk-Bet Termalica Nieciecza | 17 | 2 | 6 | 9 | 21:32 | -11 | 12 |
| 17 |
|
Warta Poznań | 17 | 2 | 6 | 9 | 11:22 | -11 | 12 |
| 18 |
|
Górnik Łęczna | 17 | 2 | 6 | 9 | 15:35 | -20 | 12 |
| Champions League Quali. | |
| Relégation |
