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| 05.11.2021 | 18:00 | Wisła Płock | - | Bruk-Bet Termalica Nieciecza | 1:1 (1:1) | |
| 20:30 | Śląsk Wrocław | - | Jagiellonia Białystok | 2:2 (1:0) | ||
| 06.11.2021 | 12:30 | Piast Gliwice | - | Warta Poznań | 0:1 (0:0) | |
| 15:00 | Radomiak Radom | - | Górnik Zabrze | 1:0 (1:0) | ||
| 17:30 | Lechia Gdańsk | - | Zagłębie Lubin | 2:1 (0:1) | ||
| 20:00 | Górnik Łęczna | - | Lech Poznań | 1:1 (0:1) | ||
| 07.11.2021 | 15:00 | Raków Częstochowa | - | Pogoń Szczecin | 0:0 (0:0) | |
| 17:30 | Legia Warszawa | - | FKS Stal Mielec | 1:3 (1:2) | ||
| 20:00 | Wisła Kraków | - | KS Cracovia | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lech Poznań | 14 | 8 | 5 | 1 | 28:8 | 20 | 29 |
| 2 |
|
Lechia Gdańsk | 14 | 8 | 5 | 1 | 25:11 | 14 | 29 |
| 3 |
|
Pogoń Szczecin | 14 | 7 | 5 | 2 | 22:10 | 12 | 26 |
| 4 |
|
Raków Częstochowa | 14 | 7 | 5 | 2 | 25:18 | 7 | 26 |
| 5 |
|
Radomiak Radom | 14 | 5 | 7 | 2 | 18:13 | 5 | 22 |
| 6 |
|
Śląsk Wrocław | 14 | 5 | 6 | 3 | 25:20 | 5 | 21 |
| 7 |
|
FKS Stal Mielec | 14 | 5 | 5 | 4 | 18:19 | -1 | 20 |
| 8 |
|
Piast Gliwice | 14 | 5 | 3 | 6 | 21:20 | 1 | 18 |
| 9 |
|
Górnik Zabrze | 14 | 5 | 3 | 6 | 16:18 | -2 | 18 |
| 10 |
|
Jagiellonia Białystok | 14 | 4 | 6 | 4 | 18:21 | -3 | 18 |
| 11 |
|
Wisła Płock | 14 | 5 | 2 | 7 | 22:22 | 0 | 17 |
| 12 |
|
KS Cracovia | 14 | 4 | 5 | 5 | 20:22 | -2 | 17 |
| 13 |
|
Wisła Kraków | 14 | 5 | 2 | 7 | 15:23 | -8 | 17 |
| 14 |
|
Zagłębie Lubin | 14 | 5 | 2 | 7 | 15:24 | -9 | 17 |
| 15 |
|
Legia Warszawa | 14 | 5 | 0 | 9 | 20:23 | -3 | 15 |
| 16 |
|
Bruk-Bet Termalica Nieciecza | 14 | 2 | 5 | 7 | 18:26 | -8 | 11 |
| 17 |
|
Warta Poznań | 14 | 2 | 5 | 7 | 9:17 | -8 | 11 |
| 18 |
|
Górnik Łęczna | 14 | 1 | 5 | 8 | 11:31 | -20 | 8 |
| Champions League Quali. | |
| Relégation |
