 |
 |
|
|
| 20.05.2022 | 23:30 | Tacuary | - | Sportivo Ameliano | 1:0 (0:0) | |
| 21.05.2022 | 22:30 | Resistencia SC | - | Sol de América | 0:0 (0:0) | |
| 22.05.2022 | 01:00 | General Caballero DJLM | - | Guaraní | 0:4 (0:0) | |
| 22:30 | Club Olimpia | - | Cerro Porteño | 0:4 (0:2) | ||
| 23.05.2022 | 01:15 | Libertad | - | Club Nacional | 1:0 (0:0) | |
| 30.05.2022 | 23:00 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:4 (0:3) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 17 | 14 | 2 | 1 | 38:13 | 25 | 44 |
| 2 |
|
Cerro Porteño | 17 | 12 | 2 | 3 | 32:11 | 21 | 38 |
| 3 |
|
Club Olimpia | 17 | 9 | 3 | 5 | 24:19 | 5 | 30 |
| 4 |
|
Resistencia SC | 17 | 7 | 7 | 3 | 28:22 | 6 | 28 |
| 5 |
|
Guaraní | 17 | 7 | 3 | 7 | 25:20 | 5 | 24 |
| 6 |
|
Sol de América | 17 | 6 | 4 | 7 | 17:21 | -4 | 22 |
| 7 |
|
Guaireña FC | 17 | 5 | 5 | 7 | 17:19 | -2 | 20 |
| 8 |
|
Club Nacional | 17 | 6 | 2 | 9 | 20:27 | -7 | 20 |
| 9 |
|
Tacuary | 17 | 6 | 2 | 9 | 14:21 | -7 | 20 |
| 10 |
|
Sportivo Ameliano | 17 | 4 | 1 | 12 | 18:29 | -11 | 13 |
| 11 |
|
General Caballero DJLM | 17 | 3 | 4 | 10 | 14:26 | -12 | 13 |
| 12 |
|
12 de Octubre de Itauguá | 17 | 2 | 7 | 8 | 13:32 | -19 | 13 |
| Copa Libertadores |
