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| 12.09.2021 | 15:00 | SG Wattenscheid 09 | - | Westfalia Rhynern | 3:2 (1:0) | |
| 15:00 | TSG Sprockhövel | - | RSV Meinerzhagen | 6:1 (3:0) | ||
| 15:00 | Hammer SpVg | - | SC Paderborn 07 II | 1:3 (0:1) | ||
| 15:00 | Sportfreunde Siegen | - | Preußen Münster II | 0:0 (0:0) | ||
| 15:00 | FCE Rheine | - | Westfalia Herne | 1:0 (1:0) | ||
| 15:00 | Viktoria Clarholz | - | SG Finnentrop/Bamenohl | 1:1 (0:1) | ||
| 15:00 | SV Schermbeck | - | Holzwickeder SC | 2:3 (1:1) | ||
| 15:00 | SpVgg Vreden | - | TuS Erndtebrück | 1:1 (0:0) | ||
| 15:00 | FC Gütersloh | - | TuS Haltern | 0:0 (0:0) | ||
| 15:15 | TuS Ennepetal | - | ASC 09 Dortmund | 2:3 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SG Wattenscheid 09 | 3 | 3 | 0 | 0 | 9:5 | 4 | 9 |
| 2 |
|
FCE Rheine | 3 | 3 | 0 | 0 | 4:1 | 3 | 9 |
| 3 |
|
1. FC Kaan-Marienborn | 2 | 2 | 0 | 0 | 9:1 | 8 | 6 |
| 4 |
|
SC Paderborn 07 II | 3 | 2 | 0 | 1 | 7:2 | 5 | 6 |
| 5 |
|
TSG Sprockhövel | 3 | 2 | 0 | 1 | 8:5 | 3 | 6 |
| 6 |
|
ASC 09 Dortmund | 3 | 2 | 0 | 1 | 9:7 | 2 | 6 |
|
TuS Ennepetal | 3 | 2 | 0 | 1 | 9:7 | 2 | 6 | |
| 8 |
|
Holzwickeder SC | 3 | 2 | 0 | 1 | 7:7 | 0 | 6 |
| 9 |
|
TuS Haltern | 3 | 1 | 2 | 0 | 3:1 | 2 | 5 |
| 10 |
|
FC Gütersloh | 2 | 1 | 1 | 0 | 2:0 | 2 | 4 |
| 11 |
|
Preußen Münster II | 3 | 1 | 1 | 1 | 4:4 | 0 | 4 |
| 12 |
|
Westfalia Rhynern | 3 | 1 | 0 | 2 | 8:6 | 2 | 3 |
| 13 |
|
SV Schermbeck | 3 | 1 | 0 | 2 | 8:7 | 1 | 3 |
| 14 |
|
Hammer SpVg | 3 | 1 | 0 | 2 | 7:7 | 0 | 3 |
| 15 |
|
Sportfreunde Siegen | 3 | 0 | 2 | 1 | 3:5 | -2 | 2 |
| 16 |
|
SpVgg Vreden | 3 | 0 | 2 | 1 | 2:4 | -2 | 2 |
| 17 |
|
TuS Erndtebrück | 3 | 0 | 2 | 1 | 4:8 | -4 | 2 |
| 18 |
|
Viktoria Clarholz | 3 | 0 | 1 | 2 | 4:8 | -4 | 1 |
| 19 |
|
SG Finnentrop/Bamenohl | 2 | 0 | 1 | 1 | 1:7 | -6 | 1 |
| 20 |
|
RSV Meinerzhagen | 3 | 0 | 0 | 3 | 4:11 | -7 | 0 |
| 21 |
|
Westfalia Herne | 3 | 0 | 0 | 3 | 1:10 | -9 | 0 |
| Play-off | |
| Relégation |
