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| 13.03.2006 | 20:00 | Helmond Sport | - | MVV | 2:0 (1:0) | |
| 20:00 | FC Omniworld | - | HFC Haarlem | 1:2 (0:0) | ||
| 20:00 | Go Ahead Eagles | - | FC Den Bosch | 0:1 (0:0) | ||
| 20:00 | TOP Oss | - | FC Zwolle | 2:1 (1:0) | ||
| 20:00 | VVV-Venlo | - | BV Veendam | 1:1 (0:0) | ||
| 20:00 | Stormvogels Telstar | - | FC Eindhoven | 0:1 (0:1) | ||
| 20:00 | AGOVV | - | SBV Excelsior | 1:1 (0:0) | ||
| 20:00 | SC Cambuur | - | FC Volendam | 2:1 (1:0) | ||
| 20:00 | FC Emmen | - | De Graafschap | 2:2 (1:0) | ||
| 20:00 | Fortuna Sittard | - | FC Dordrecht | 0:3 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 34 | 19 | 8 | 7 | 61:22 | 39 | 65 |
| 2 |
|
VVV-Venlo | 34 | 17 | 8 | 9 | 45:30 | 15 | 59 |
| 3 |
|
FC Emmen | 34 | 17 | 6 | 11 | 61:43 | 18 | 57 |
| 4 |
|
FC Volendam | 34 | 16 | 9 | 9 | 48:36 | 12 | 57 |
| 5 |
|
Helmond Sport | 34 | 17 | 6 | 11 | 54:49 | 5 | 57 |
| 6 |
|
FC Den Bosch | 34 | 15 | 10 | 9 | 57:47 | 10 | 55 |
| 7 |
|
HFC Haarlem | 34 | 16 | 7 | 11 | 55:48 | 7 | 55 |
| 8 |
|
De Graafschap | 34 | 15 | 9 | 10 | 53:44 | 9 | 54 |
| 9 |
|
FC Zwolle | 34 | 14 | 9 | 11 | 53:44 | 9 | 51 |
| 10 |
|
FC Dordrecht | 34 | 13 | 11 | 10 | 51:37 | 14 | 50 |
| 11 |
|
AGOVV | 34 | 15 | 5 | 14 | 58:56 | 2 | 50 |
| 12 |
|
TOP Oss | 34 | 13 | 10 | 11 | 45:47 | -2 | 49 |
| 13 |
|
MVV | 34 | 12 | 10 | 12 | 48:47 | 1 | 46 |
| 14 |
|
BV Veendam | 34 | 12 | 8 | 14 | 47:54 | -7 | 44 |
| 15 |
|
SC Cambuur | 34 | 9 | 13 | 12 | 38:45 | -7 | 37 |
| 16 |
|
Stormvogels Telstar | 34 | 8 | 12 | 14 | 32:48 | -16 | 36 |
| 17 |
|
FC Eindhoven | 34 | 10 | 5 | 19 | 46:55 | -9 | 35 |
| 18 |
|
Go Ahead Eagles | 34 | 7 | 11 | 16 | 41:62 | -21 | 32 |
| 19 |
|
FC Omniworld | 34 | 7 | 6 | 21 | 43:76 | -33 | 27 |
| 20 |
|
Fortuna Sittard | 34 | 2 | 9 | 23 | 30:76 | -46 | 15 |
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