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| 09.03.2006 | 20:00 | TOP Oss | - | AGOVV | 0:1 (0:1) | |
| 10.03.2006 | 20:00 | FC Volendam | - | Fortuna Sittard | 2:0 (0:0) | |
| 20:00 | De Graafschap | - | SC Cambuur | 3:3 (1:2) | ||
| 20:00 | FC Den Bosch | - | SBV Excelsior | 0:1 (0:0) | ||
| 20:00 | FC Eindhoven | - | Go Ahead Eagles | 2:1 (1:0) | ||
| 20:00 | BV Veendam | - | Stormvogels Telstar | 0:2 (0:1) | ||
| 20:00 | FC Zwolle | - | FC Omniworld | 2:1 (1:1) | ||
| 20:00 | HFC Haarlem | - | Helmond Sport | 0:1 (0:1) | ||
| 20:00 | MVV | - | FC Emmen | 0:1 (0:0) | ||
| 20:00 | FC Dordrecht | - | VVV-Venlo | 5:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 33 | 19 | 7 | 7 | 60:21 | 39 | 64 |
| 2 |
|
VVV-Venlo | 33 | 17 | 7 | 9 | 44:29 | 15 | 58 |
| 3 |
|
FC Volendam | 33 | 16 | 9 | 8 | 47:34 | 13 | 57 |
| 4 |
|
FC Emmen | 33 | 17 | 5 | 11 | 59:41 | 18 | 56 |
| 5 |
|
Helmond Sport | 33 | 16 | 6 | 11 | 52:49 | 3 | 54 |
| 6 |
|
De Graafschap | 33 | 15 | 8 | 10 | 51:42 | 9 | 53 |
| 7 |
|
FC Den Bosch | 33 | 14 | 10 | 9 | 56:47 | 9 | 52 |
| 8 |
|
HFC Haarlem | 33 | 15 | 7 | 11 | 53:47 | 6 | 52 |
| 9 |
|
FC Zwolle | 33 | 14 | 9 | 10 | 52:42 | 10 | 51 |
| 10 |
|
AGOVV | 33 | 15 | 4 | 14 | 57:55 | 2 | 49 |
| 11 |
|
FC Dordrecht | 33 | 12 | 11 | 10 | 48:37 | 11 | 47 |
| 12 |
|
MVV | 33 | 12 | 10 | 11 | 48:45 | 3 | 46 |
| 13 |
|
TOP Oss | 33 | 12 | 10 | 11 | 43:46 | -3 | 46 |
| 14 |
|
BV Veendam | 33 | 12 | 7 | 14 | 46:53 | -7 | 43 |
| 15 |
|
Stormvogels Telstar | 33 | 8 | 12 | 13 | 32:47 | -15 | 36 |
| 16 |
|
SC Cambuur | 33 | 8 | 13 | 12 | 36:44 | -8 | 34 |
| 17 |
|
FC Eindhoven | 33 | 9 | 5 | 19 | 45:55 | -10 | 32 |
| 18 |
|
Go Ahead Eagles | 33 | 7 | 11 | 15 | 41:61 | -20 | 32 |
| 19 |
|
FC Omniworld | 33 | 7 | 6 | 20 | 42:74 | -32 | 27 |
| 20 |
|
Fortuna Sittard | 33 | 2 | 9 | 22 | 30:73 | -43 | 15 |
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