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| 20.01.2006 | 20:00 | FC Den Bosch | - | MVV | 3:1 (1:1) | |
| 20:00 | VVV-Venlo | - | FC Omniworld | 0:1 (0:1) | ||
| 20:00 | Fortuna Sittard | - | Helmond Sport | 2:3 (1:0) | ||
| 20:00 | SBV Excelsior | - | HFC Haarlem | 1:2 (0:0) | ||
| 20:00 | SC Cambuur | - | FC Emmen | 1:1 (0:0) | ||
| 20:00 | AGOVV | - | FC Dordrecht | 2:1 (2:1) | ||
| 20:00 | BV Veendam | - | FC Volendam | 2:3 (2:2) | ||
| 20:00 | Stormvogels Telstar | - | TOP Oss | 1:1 (0:1) | ||
| 22.01.2006 | 13:00 | Go Ahead Eagles | - | FC Zwolle | 1:1 (1:1) | |
| 23.01.2006 | 20:00 | FC Eindhoven | - | De Graafschap | 2:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 26 | 16 | 5 | 5 | 53:17 | 36 | 53 |
| 2 |
|
VVV-Venlo | 26 | 15 | 7 | 4 | 39:14 | 25 | 52 |
| 3 |
|
FC Emmen | 26 | 14 | 4 | 8 | 49:32 | 17 | 46 |
| 4 |
|
FC Volendam | 26 | 13 | 7 | 6 | 40:29 | 11 | 46 |
| 5 |
|
FC Den Bosch | 26 | 12 | 9 | 5 | 49:37 | 12 | 45 |
| 6 |
|
Helmond Sport | 26 | 13 | 5 | 8 | 42:40 | 2 | 44 |
| 7 |
|
FC Zwolle | 26 | 11 | 7 | 8 | 43:36 | 7 | 40 |
| 8 |
|
De Graafschap | 26 | 11 | 6 | 9 | 39:32 | 7 | 39 |
| 9 |
|
MVV | 26 | 10 | 8 | 8 | 38:34 | 4 | 38 |
| 10 |
|
AGOVV | 26 | 11 | 3 | 12 | 46:45 | 1 | 36 |
| 11 |
|
HFC Haarlem | 26 | 10 | 6 | 10 | 37:45 | -8 | 36 |
| 12 |
|
FC Dordrecht | 26 | 8 | 9 | 9 | 30:30 | 0 | 33 |
| 13 |
|
BV Veendam | 26 | 9 | 6 | 11 | 38:40 | -2 | 33 |
| 14 |
|
TOP Oss | 26 | 7 | 10 | 9 | 32:41 | -9 | 31 |
| 15 |
|
Go Ahead Eagles | 26 | 6 | 9 | 11 | 31:44 | -13 | 27 |
| 16 |
|
Stormvogels Telstar | 26 | 6 | 9 | 11 | 22:36 | -14 | 27 |
| 17 |
|
FC Omniworld | 26 | 7 | 5 | 14 | 35:56 | -21 | 26 |
| 18 |
|
FC Eindhoven | 26 | 6 | 5 | 15 | 35:45 | -10 | 23 |
| 19 |
|
SC Cambuur | 26 | 5 | 10 | 11 | 27:39 | -12 | 22 |
| 20 |
|
Fortuna Sittard | 26 | 1 | 8 | 17 | 25:58 | -33 | 11 |
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