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| 19.02.2021 | 18:45 | FC Dordrecht | - | NAC Breda | 2:3 (1:2) | |
| 18:45 | Jong PSV | - | FC Den Bosch | 1:0 (1:0) | ||
| 21:00 | Helmond Sport | - | Roda JC Kerkrade | 1:2 (1:1) | ||
| 21:00 | Telstar | - | FC Eindhoven | 1:1 (1:0) | ||
| 20.02.2021 | 14:00 | TOP Oss | - | Almere City FC | 2:4 (0:2) | |
| 16:30 | MVV | - | SBV Excelsior | 1:0 (0:0) | ||
| 21.02.2021 | 12:15 | NEC Nijmegen | - | De Graafschap | 1:2 (0:0) | |
| 22.02.2021 | 18:45 | AZ Alkmaar (J) | - | Go Ahead Eagles | 0:3 (0:1) | |
| 21:00 | FC Utrecht (J) | - | SC Cambuur | 1:3 (0:1) | ||
| 23.02.2021 | 18:45 | FC Volendam | - | Jong Ajax | 3:2 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 25 | 19 | 3 | 3 | 72:21 | 51 | 60 |
| 2 |
|
De Graafschap | 25 | 18 | 2 | 5 | 53:34 | 19 | 56 |
| 3 |
|
Almere City FC | 25 | 16 | 5 | 4 | 56:34 | 22 | 53 |
| 4 |
|
NAC Breda | 25 | 15 | 5 | 5 | 48:23 | 25 | 50 |
| 5 |
|
Go Ahead Eagles | 25 | 14 | 5 | 6 | 36:18 | 18 | 47 |
| 6 |
|
NEC Nijmegen | 25 | 13 | 5 | 7 | 45:30 | 15 | 44 |
| 7 |
|
FC Volendam | 25 | 12 | 7 | 6 | 53:33 | 20 | 43 |
| 8 |
|
Roda JC Kerkrade | 25 | 11 | 8 | 6 | 47:33 | 14 | 41 |
| 9 |
|
Telstar | 25 | 9 | 7 | 9 | 43:36 | 7 | 34 |
| 10 |
|
SBV Excelsior | 25 | 9 | 3 | 13 | 45:44 | 1 | 30 |
| 11 |
|
Helmond Sport | 25 | 7 | 9 | 9 | 35:39 | -4 | 30 |
| 12 |
|
Jong Ajax | 25 | 8 | 6 | 11 | 41:47 | -6 | 30 |
| 13 |
|
FC Eindhoven | 25 | 7 | 7 | 11 | 36:44 | -8 | 28 |
| 14 |
|
FC Utrecht (J) | 25 | 9 | 1 | 15 | 38:48 | -10 | 28 |
| 15 |
|
TOP Oss | 25 | 8 | 4 | 13 | 27:40 | -13 | 28 |
| 16 |
|
Jong PSV | 25 | 6 | 6 | 13 | 37:53 | -16 | 24 |
| 17 |
|
MVV | 25 | 6 | 5 | 14 | 26:52 | -26 | 23 |
| 18 |
|
AZ Alkmaar (J) | 25 | 6 | 4 | 15 | 35:68 | -33 | 22 |
| 19 |
|
FC Dordrecht | 25 | 4 | 3 | 18 | 23:66 | -43 | 15 |
| 20 |
|
FC Den Bosch | 25 | 2 | 7 | 16 | 27:60 | -33 | 13 |
| Promotion | |
| Play-off |
