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| 06.05.2000 | 20:00 | NAC Breda | - | RBC Roosendaal | 2:0 (1:0) | |
| 20:00 | Dordrecht '90 | - | ADO Den Haag | 1:0 (0:0) | ||
| 20:00 | BV Emmen | - | Helmond Sport | 2:3 (0:1) | ||
| 20:00 | Go Ahead Eagles | - | HFC Haarlem | 1:1 (0:0) | ||
| 20:00 | FC Groningen | - | FC Volendam | 3:0 (1:0) | ||
| 20:00 | Heracles Almelo | - | SBV Excelsior | 1:3 (0:2) | ||
| 20:00 | TOP Oss | - | FC Zwolle | 1:3 (0:2) | ||
| 20:00 | Telstar | - | SBV Eindhoven | 2:1 (2:0) | ||
| 20:00 | VVV | - | BV Veendam | 1:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
NAC Breda | 33 | 26 | 1 | 6 | 80:34 | 46 | 79 |
| 2 |
|
FC Zwolle | 33 | 22 | 7 | 4 | 87:38 | 49 | 73 |
| 3 |
|
FC Groningen | 33 | 22 | 5 | 6 | 77:31 | 46 | 71 |
| 4 |
|
BV Emmen | 33 | 18 | 4 | 11 | 52:42 | 10 | 58 |
| 5 |
|
SBV Excelsior | 33 | 17 | 5 | 11 | 67:47 | 20 | 56 |
| 6 |
|
RBC Roosendaal | 33 | 17 | 5 | 11 | 63:47 | 16 | 56 |
| 7 |
|
Heracles Almelo | 33 | 13 | 7 | 13 | 39:40 | -1 | 46 |
| 8 |
|
SBV Eindhoven | 33 | 14 | 3 | 16 | 45:59 | -14 | 45 |
| 9 |
|
Dordrecht '90 | 33 | 11 | 9 | 13 | 51:56 | -5 | 42 |
| 10 |
|
Helmond Sport | 33 | 12 | 3 | 18 | 43:56 | -13 | 39 |
| 11 |
|
ADO Den Haag | 33 | 11 | 6 | 16 | 36:52 | -16 | 39 |
| 12 |
|
BV Veendam | 33 | 9 | 11 | 13 | 47:60 | -13 | 38 |
| 13 |
|
Go Ahead Eagles | 33 | 9 | 9 | 15 | 55:56 | -1 | 36 |
| 14 |
|
Telstar | 33 | 11 | 3 | 19 | 41:56 | -15 | 36 |
| 15 |
|
VVV | 33 | 8 | 11 | 14 | 38:61 | -23 | 35 |
| 16 |
|
HFC Haarlem | 33 | 9 | 5 | 19 | 52:68 | -16 | 32 |
| 17 |
|
FC Volendam | 33 | 8 | 7 | 18 | 38:71 | -33 | 31 |
| 18 |
|
TOP Oss | 33 | 8 | 3 | 22 | 34:71 | -37 | 27 |
