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| 29.05.2022 | 14:00 | ADO '20 | - | JOS Watergraafsmeer | 4:2 (1:2) | |
| 14:00 | Quick Den Haag | - | USV Hercules | 0:1 (0:0) | ||
| 14:00 | Blauw Geel '38 | - | VV Dongen | 0:2 (0:1) | ||
| 14:00 | EVV | - | HVV Hollandia | 1:0 (0:0) | ||
| 14:00 | OSS '20 | - | HSC'21 | 3:0 (0:0) | ||
| 14:00 | RKVV Westlandia | - | RKSV Groene Ster | 3:0 (0:0) | ||
| 14:00 | Unitas Gorinchem | - | RKVV DEM | 0:2 (0:0) | ||
| 14:00 | VV Gemert | - | OFC Oostzaan | 1:1 (1:1) | ||
| 14:00 | VV UNA | - | VV Hoogland | 1:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
USV Hercules | 33 | 18 | 4 | 11 | 71:43 | 28 | 58 |
| 2 |
|
OFC Oostzaan | 33 | 17 | 7 | 9 | 63:47 | 16 | 58 |
| 3 |
|
VV Gemert | 33 | 15 | 12 | 6 | 74:55 | 19 | 57 |
| 4 |
|
ADO '20 | 33 | 17 | 6 | 10 | 61:43 | 18 | 57 |
| 5 |
|
OSS '20 | 33 | 15 | 8 | 10 | 58:43 | 15 | 52 |
| 6 |
|
RKSV Groene Ster | 33 | 14 | 9 | 10 | 45:46 | -1 | 51 |
| 7 |
|
VV Dongen | 33 | 13 | 11 | 9 | 56:45 | 11 | 50 |
| 8 |
|
VV UNA | 33 | 15 | 5 | 13 | 59:56 | 3 | 50 |
| 9 |
|
Quick Den Haag | 33 | 14 | 5 | 14 | 47:41 | 6 | 47 |
| 10 |
|
HSC'21 | 33 | 14 | 4 | 15 | 61:51 | 10 | 46 |
| 11 |
|
Blauw Geel '38 | 33 | 13 | 5 | 15 | 53:54 | -1 | 44 |
| 12 |
|
RKVV DEM | 33 | 12 | 6 | 15 | 35:49 | -14 | 42 |
| 13 |
|
Unitas Gorinchem | 33 | 12 | 6 | 15 | 40:57 | -17 | 42 |
| 14 |
|
JOS Watergraafsmeer | 33 | 12 | 5 | 16 | 57:67 | -10 | 39 |
| 15 |
|
VV Hoogland | 33 | 10 | 6 | 17 | 40:63 | -23 | 36 |
| 16 |
|
EVV | 33 | 8 | 10 | 15 | 34:59 | -25 | 34 |
| 17 |
|
RKVV Westlandia | 33 | 8 | 8 | 17 | 42:59 | -17 | 32 |
| 18 |
|
HVV Hollandia | 33 | 9 | 5 | 19 | 36:54 | -18 | 32 |
| Promotion | |
| Relégation | |
| Relégation |
